Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 2-Chloro-3'-fluoro-3,4'-dihydroxy-[1,1-biphenyl]-4-carboxaldehydeoxime
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Purity: 98.0%
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1111084-78-6

1111084-78-6 structure

1111084-78-6 structure

Name: FERb 033
Chemical Name: 2-Chloro-3'-fluoro-4-[(E)-(hydroxyimino)methyl]-3,4'-biphenyldiol
CAS Number: 1111084-78-6
Molecular Formula: C₁₃H₉ClFNO₃
Molecular Weight: 281.66700
Catalog: Research Areas Endocrinology
Create Date: 2017-01-10 05:36:12
Modify Date: 2024-01-08 12:12:29
FERb 033 is a selective and potent ERβ agonist (Ki=7.1 nM, EC50=4.8 nM). FERb 033 shows 62-fold selectivity over ERα[1].

Name	2-Chloro-3'-fluoro-4-[(E)-(hydroxyimino)methyl]-3,4'-biphenyldiol
Synonyms	DMPQ dihydrochloride 2-Pentenoic acid,3-(chlorocarbonyl)-4-methyl-,methyl ester,(E) (E)-3-carbomethoxy-2-(1-methylethyl)prop-2-enoyl chloride (E)-3-chloro-4-(3-fluoro-4-hydroxyphenyl)salicylaldoxime

Description	FERb 033 is a selective and potent ERβ agonist (Ki=7.1 nM, EC50=4.8 nM). FERb 033 shows 62-fold selectivity over ERα[1].
Related Catalog	Signaling Pathways >> Others >> Estrogen Receptor/ERR Research Areas >> Endocrinology
Target	ERβ:4.8 nM (EC50) ERβ:7.1 nM (Ki)
In Vitro	FERb 033 (0-100 μM) shows specificity on full-length of estrogen receptor (ESR) in transactivation[2]. FERb 033 (10 nM, 2 h) treatment mildly decreases Ca2+ response in airway smooth muscle (ASM) cells[3]. Cell Viability Assay[2] Cell Line: HEK293 cells Concentration: 0-100 μM Incubation Time: Result: Induced transcriptional activity via full-length receptor on ERE with EC50 values of 0.253 and 0.053 μM for ESR1 and ESR2, respectively. Cell Viability Assay[3] Cell Line: ASM cells Concentration: 10 nM Incubation Time: 2 hours Result: Tended to decrease histamine-elicited Ca2+ response in nonasthmatic human ASM cells but not significantly compared to the control.
References	[1]. Filippo Minutolo, et al. Structural evolutions of salicylaldoximes as selective agonists for estrogen receptor beta. J Med Chem. 2009 Feb 12;52(3):858-67. [2]. Satomi Kohno, et al. Estrogen receptor 1 (ESR1; ERα), not ESR2 (ERβ), modulates estrogen-induced sex reversal in the American alligator, a species with temperature-dependent sex determination. Endocrinology. 2015 May;156(5):1887-99. [3]. Sangeeta Bhallamudi, et al. Estrogen receptors differentially regulate intracellular calcium handling in human nonasthmatic and asthmatic airway smooth muscle cells. Am J Physiol Lung Cell Mol Physiol. 2020 Jan 1;318(1):L112-L124.

Molecular Formula	C₁₃H₉ClFNO₃
Molecular Weight	281.66700
Exact Mass	281.02500
PSA	73.05000
LogP	3.36540