1111084-78-6
1111084-78-6 structure
- Name: FERb 033
- Chemical Name: 2-Chloro-3'-fluoro-4-[(E)-(hydroxyimino)methyl]-3,4'-biphenyldiol
- CAS Number: 1111084-78-6
- Molecular Formula: C13H9ClFNO3
- Molecular Weight: 281.66700
- Catalog: Research Areas Endocrinology
- Create Date: 2017-01-10 05:36:12
- Modify Date: 2024-01-08 12:12:29
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FERb 033 is a selective and potent ERβ agonist (Ki=7.1 nM, EC50=4.8 nM). FERb 033 shows 62-fold selectivity over ERα[1].
| Name | 2-Chloro-3'-fluoro-4-[(E)-(hydroxyimino)methyl]-3,4'-biphenyldiol |
|---|---|
| Synonyms |
DMPQ dihydrochloride
2-Pentenoic acid,3-(chlorocarbonyl)-4-methyl-,methyl ester,(E) (E)-3-carbomethoxy-2-(1-methylethyl)prop-2-enoyl chloride (E)-3-chloro-4-(3-fluoro-4-hydroxyphenyl)salicylaldoxime |
| Description | FERb 033 is a selective and potent ERβ agonist (Ki=7.1 nM, EC50=4.8 nM). FERb 033 shows 62-fold selectivity over ERα[1]. |
|---|---|
| Related Catalog | |
| Target |
ERβ:4.8 nM (EC50) ERβ:7.1 nM (Ki) |
| In Vitro | FERb 033 (0-100 μM) shows specificity on full-length of estrogen receptor (ESR) in transactivation[2]. FERb 033 (10 nM, 2 h) treatment mildly decreases Ca2+ response in airway smooth muscle (ASM) cells[3]. Cell Viability Assay[2] Cell Line: HEK293 cells Concentration: 0-100 μM Incubation Time: Result: Induced transcriptional activity via full-length receptor on ERE with EC50 values of 0.253 and 0.053 μM for ESR1 and ESR2, respectively. Cell Viability Assay[3] Cell Line: ASM cells Concentration: 10 nM Incubation Time: 2 hours Result: Tended to decrease histamine-elicited Ca2+ response in nonasthmatic human ASM cells but not significantly compared to the control. |
| References |
| Molecular Formula | C13H9ClFNO3 |
|---|---|
| Molecular Weight | 281.66700 |
| Exact Mass | 281.02500 |
| PSA | 73.05000 |
| LogP | 3.36540 |