21306-65-0
21306-65-0 structure
- Name: TPh A
- Chemical Name: (NE)-4-methyl-N-[methyl-(4-phenylmethoxyphenyl)-λ4-sulfanylidene]benzenesulfonamide
- CAS Number: 21306-65-0
- Molecular Formula: C21H21NO3S2
- Molecular Weight: 399.52600
- Catalog: Signaling Pathways Others Others
- Create Date: 2016-08-03 18:19:24
- Modify Date: 2024-01-03 06:41:44
-
TPh A (Triphenyl Compound A) is a potent inhibitor of the nuclear protein pirin and binds specifically to pirin with a Ki of 0.6 uM. TPh A disrupts the formation of the bcl3–pirin complex. TPh A can be used as a novel small molecule tool to regulate pirin in cells[1].
| Name | (NE)-4-methyl-N-[methyl-(4-phenylmethoxyphenyl)-λ4-sulfanylidene]benzenesulfonamide |
|---|---|
| Synonyms |
NPD-123
Triphenyl compound A TPh A |
| Description | TPh A (Triphenyl Compound A) is a potent inhibitor of the nuclear protein pirin and binds specifically to pirin with a Ki of 0.6 uM. TPh A disrupts the formation of the bcl3–pirin complex. TPh A can be used as a novel small molecule tool to regulate pirin in cells[1]. |
|---|---|
| Related Catalog | |
| In Vitro | The Pirin is a nuclear protein with the nuclear factor I/CCAAT box transcription factor (NFI/CTF). Pirin proteins are highly conserved between mammals, plants, fungi, and prokaryotic organisms and are considered to belong to the cupin superfamily. TPh A (20 μM; 5 hours) reduces the amount of pirin-bound Bcl3 and inhibits the interaction between pirin and Bcl3 in HEK293T cells in a glutathione S-transferase (GST) pulldown assay (HEK293T cells are transfected with vectors that encoded bcl3-Myc and pirin-His6 for 43 h of transfection)[1]. TPh A (0-100 μM; 48 hours) does not exert any potent cytotoxic activity against many human cancer cell lines, it against MCF7, MDA-MB231, HeLa, DU145, HepG2, A549, HT1080, WM266-4, and SK-MEL-28 cells with IC50 values >50 μM, and exhibits IC50 values of 27 μM, 20 μM and 26 μM for PC3 HL60 and HT29 cells, respectively[1]. TPhA (0-50 μM; 48 hours) inhibits cell migration in WM266-4 cells, SK-MEL-28 cell in a concentration-dependent manner[1]. Cell Viability Assay[1] Cell Line: MCF7, MDA-MB231, HeLa, DU145, HepG2, A549, HT1080, WM266-4, and SK-MEL-28 cells Concentration: 0-100 μM Incubation Time: 48 hours Result: Did not exert any potent cytotoxic activity against many human cancer cell lines. |
| References |
| Molecular Formula | C21H21NO3S2 |
|---|---|
| Molecular Weight | 399.52600 |
| Exact Mass | 399.09600 |
| PSA | 83.32000 |
| LogP | 6.48490 |
| RIDADR | NONH for all modes of transport |
|---|