298704-22-0

298704-22-0 structure

Name: p-Hydroxybenzaldehyde-d5
Chemical Name: 4-hydroxy-[2,3,5,6,7-2H5]-benzaldehyde
CAS Number: 298704-22-0
Molecular Formula: C₇HD₅O₂
Molecular Weight: 127.15200
Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
Create Date: 2017-02-17 03:20:07
Modify Date: 2024-01-11 07:47:32
p-Hydroxybenzaldehyde-d5 is the deuterium labeled p-Hydroxybenzaldehyde[1]. p-Hydroxybenzaldehyde is a one of the major components in vanilla aroma, with antagonistic effect on GABAA receptor of the α1β2γ2S subtype at high concentrations[2].

Name	4-hydroxy-[2,3,5,6,7-2H5]-benzaldehyde
Synonyms	4-hydroxy-2,3,5,6-d4-benz(aldehyde-d1) 4-Hydroxybenzaldehyde-Alpha,2,3,5,6-d5 2,3,5,6-d4-4-hydroxy-benzaldehyde-d1

Description	p-Hydroxybenzaldehyde-d5 is the deuterium labeled p-Hydroxybenzaldehyde[1]. p-Hydroxybenzaldehyde is a one of the major components in vanilla aroma, with antagonistic effect on GABAA receptor of the α1β2γ2S subtype at high concentrations[2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References	[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Zhang J, et al. The Effect of 4-hydroxybenzaldehyde on the γ-aminobutyric Acid Type A Receptor. Malays J Med Sci. 2017 Mar;24(2):94-99.