66611-26-5
66611-26-5 structure
- Name: RU 24969
- Chemical Name: 5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole
- CAS Number: 66611-26-5
- Molecular Formula: C14H16N2O
- Molecular Weight: 228.29000
- Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
- Create Date: 2018-12-31 01:30:26
- Modify Date: 2025-08-25 03:42:20
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RU 24969 is a selective agonist at the 5-HT1A and 5-HT1B receptors; IC50 value:Target: 5-HT1A/1B agonistRU 24969 possesses preference for the purported 5-HT1B subtype of central 5-HT1 recognition site. The reported significant linear correlation between hypotensive activity following intravenous (i.v.) administration to anesthetized rats and affinity for the central 5-HT1 binding site could only be maintained by incorporation of the affinity of RU 24969 for its low and 8-OH-DPAT for its high affinity binding site [1]. The drug RU 24969 (10 mg/kg) inhibited the rate of synthesis of 5-HT in rat brain by about 50%. Pretreatment of rats with desmethylimipramine over a longer term or clenbuterol given acutely, treatments known to enhance the behavioural responses of rats to various other 5-HT agonists, did not alter the RU 24969-induced response [2]. RU 24969 (0.03-3.0mg/kg, s.c.) dose-dependently decreased water consumption in water deprived rats [3].
| Name | 5-methoxy-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indole |
|---|---|
| Synonyms |
Tocris-0912
RU 24969 |
| Description | RU 24969 is a selective agonist at the 5-HT1A and 5-HT1B receptors; IC50 value:Target: 5-HT1A/1B agonistRU 24969 possesses preference for the purported 5-HT1B subtype of central 5-HT1 recognition site. The reported significant linear correlation between hypotensive activity following intravenous (i.v.) administration to anesthetized rats and affinity for the central 5-HT1 binding site could only be maintained by incorporation of the affinity of RU 24969 for its low and 8-OH-DPAT for its high affinity binding site [1]. The drug RU 24969 (10 mg/kg) inhibited the rate of synthesis of 5-HT in rat brain by about 50%. Pretreatment of rats with desmethylimipramine over a longer term or clenbuterol given acutely, treatments known to enhance the behavioural responses of rats to various other 5-HT agonists, did not alter the RU 24969-induced response [2]. RU 24969 (0.03-3.0mg/kg, s.c.) dose-dependently decreased water consumption in water deprived rats [3]. |
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| Related Catalog | |
| References |
| Molecular Formula | C14H16N2O |
|---|---|
| Molecular Weight | 228.29000 |
| Exact Mass | 228.12600 |
| PSA | 37.05000 |
| LogP | 2.88200 |
| Storage condition | 2-8℃ |
| HS Code | 2933990090 |
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|
~88%
66611-26-5 |
| Literature: BIO-MEDISINSK INNOVASJON AS; COCKBAIN, Julian Patent: WO2007/7072 A1, 2007 ; Location in patent: Page/Page column 21-22 ; WO 2007/007072 A1 |
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66611-26-5 |
| Literature: Eli Lilly and Company Patent: US5614523 A1, 1997 ; US 5614523 A |
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66611-26-5 |
| Literature: Eli Lilly and Company Patent: US5846982 A1, 1998 ; US 5846982 A |
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66611-26-5 |
| Literature: Mattsson, Cecilia; Sonesson, Clas; Sandahl, Anna; Greiner, Hartmut E.; Gassen, Michael; Plaschke, Joerg; Leibrock, Joachim; Boettcher, Henning Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 19 p. 4230 - 4234 |
| Precursor 4 | |
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| DownStream 1 | |
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |