14260-82-3

14260-82-3 structure

Name: 3′-Deoxy-3′-iodothymidine
Chemical Name: 3'-deoxy-3'-iodothymidine
CAS Number: 14260-82-3
Molecular Formula: C₁₀H₁₃IN₂O₄
Molecular Weight: 352.13
Catalog: Signaling Pathways Cell Cycle/DNA Damage Nucleoside Antimetabolite/Analog
Create Date: 2017-03-20 01:22:46
Modify Date: 2026-07-13 14:46:53
3′-Deoxy-3′-iodothymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Name	3'-deoxy-3'-iodothymidine
Synonyms	3'-Iodo-3'-deoxy-D-thymidine 3’-Deoxy-3’-iodothymidine THYMIDINE,3'-DEOXY-3'-IODO 3'-DEOXY-3'-IODOTHYMIDINE 3’-Deoxy-3’-iodo thymidine, IddT, 2’,3’-Dideoxy-3’-iodo-5-methyluridine 3’-Deoxy-3’-iodothymidine, IddT, 3’-Deoxy-3’-iodo-5-methyluridine 3'-Deoxy-3'-iodothymidin THYMIDINE, 3'-DEOXY-3'-IODO 3'-IODOTHYMIDINE 3'-iodo-3'-deoxythymidine 1-(3-iodo-2,3-dideoxy-β-D-erythro-pentofuranosyl)thymine

Description	3′-Deoxy-3′-iodothymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
References	[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

25442-44-8

14260-82-3

Literature: Journal of Medicinal Chemistry, , vol. 53, # 10 p. 4130 - 4140