219138-21-3

219138-21-3 structure

Name: Ac-Ile-Glu-Thr-Asp-pNA
Chemical Name: ac-ietd-pna
CAS Number: 219138-21-3
Molecular Formula: C₂₇H₃₈N₆O₁₂
Molecular Weight: 638.624
Catalog: Research Areas Others
Create Date: 2018-11-24 12:19:14
Modify Date: 2025-08-22 11:11:44
Ac-Ile-Glu-Thr-Asp-pNA is a substrate for caspase-8. Caspase-8 binds to and cleaves the Ile-Glu-Thr-Asp (IETD) peptide sequence to release p-nitroalinide, which can be quantified by colorimetric detection at 405 nm as a measure of enzyme activity[1].

Name	ac-ietd-pna
Synonyms	ac-ietd-amc z-ala-ala-asp-afc N-Acetyl-L-isoleucyl-L-α-glutamyl-L-threonyl-N-(4-nitrophenyl)-L-α-asparagine ac-ile-glu-thr-asp-mca ac-ietd-mca L-α-Asparagine, N-acetyl-L-isoleucyl-L-α-glutamyl-L-threonyl-N-(4-nitrophenyl)- pase-8 substrate pase-8 substrate i ac-ile-glu-thr-asp-amc ax-ietd-amc granzyme b substrate

Description	Ac-Ile-Glu-Thr-Asp-pNA is a substrate for caspase-8. Caspase-8 binds to and cleaves the Ile-Glu-Thr-Asp (IETD) peptide sequence to release p-nitroalinide, which can be quantified by colorimetric detection at 405 nm as a measure of enzyme activity[1].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Smith GK, et al. Expression, preparation, and high-throughput screening of caspase-8: discovery of redox-based and steroid diacid inhibition. Arch Biochem Biophys. 2002;399(2):195-205.