67199-66-0

67199-66-0 structure

Name: Bay H 2049
Chemical Name: 8-amino-10H-isoindolo[1,2-b]quinazolin-12-one
CAS Number: 67199-66-0
Molecular Formula: C₁₅H₁₁N₃O
Molecular Weight: 249.27
Catalog: Signaling Pathways Cell Cycle/DNA Damage Topoisomerase
Create Date: 2018-08-11 12:08:54
Modify Date: 2024-01-09 16:33:41
Batracylin (NSC320846) is a potent DNA Topoisomerases I and DNA Topoisomerases II inhibitor. Batracylin shows cytotoxicity and antiproliferative activity. Batracylin induces DNA breaks[1].

Name	8-amino-10H-isoindolo[1,2-b]quinazolin-12-one
Synonyms	batracyclin Batracylin Daniquidona [INN-Spanish] 8-aminoisoindolo<1,2-b>quinazolin-12(10H)-one Isoindolo(1,2-b)quinazolin-12(10H)-one,8-amino Daniquidonum [INN-Latin] Daniquidone

Description	Batracylin (NSC320846) is a potent DNA Topoisomerases I and DNA Topoisomerases II inhibitor. Batracylin shows cytotoxicity and antiproliferative activity. Batracylin induces DNA breaks[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Topoisomerase
References	[1]. Rao VA, et al. Batracylin (NSC 320846), a dual inhibitor of DNA topoisomerases I and II induces histone gamma-H2AX as a biomarker of DNA damage. Cancer Res. 2007 Oct 15;67(20):9971-9.

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 126,39,1994