DC Chemicals Limited
China
Product Name: BW245C
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Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

72814-32-5

72814-32-5 structure

72814-32-5 structure

Name: BW 245C
Chemical Name: bw 245c
CAS Number: 72814-32-5
Molecular Formula: C₁₉H₃₂N₂O₅
Molecular Weight: 368.468
Catalog: Signaling Pathways GPCR/G Protein Prostaglandin Receptor
Create Date: 2016-03-05 21:27:42
Modify Date: 2024-01-03 22:48:55
BW 245C is a prostanoid DP-receptor (DP1) agonist, used to treat stroke.

Name	bw 245c
Synonyms	4-Imidazolidineheptanoic acid, 3-(3-cyclohexyl-3-hydroxypropyl)-2,5-dioxo- 7-[3-(3-Cyclohexyl-3-hydroxypropyl)-2,5-dioxoimidazolidin-4-yl]heptanoic acid 7-[3-(3-Cyclohexyl-3-hydroxypropyl)-2,5-dioxo-4-imidazolidinyl]heptanoic acid 4-Imidazolidineheptanoic acid, 3-(3-cyclohexyl-3-hydroxypropyl)-2,5-dioxo-, (R,S)-( -)-

Description	BW 245C is a prostanoid DP-receptor (DP1) agonist, used to treat stroke.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Prostaglandin Receptor Research Areas >> Cardiovascular Disease
Target	DP/DP1 Receptor
In Vitro	BW245C (0.01-1 μM) suppresses TGF-β-induced collagen secretion in a dose-dependent manner in Th2 cells. BW245C (0.01-1 μM) also increases intracellular cAMP in lung fibroblasts[3]. BW245C (0.1-3 μmol/L) dose-dependently increases transendothelial electrical resistance and decreases the FITC-dextran permeability of human umbilical vein endothelial cells. BW245C (0.3 μmol/L) increases the intracellular cAMP level and subsequent protein kinase A (PKA) activity[4].
In Vivo	BW245C (0.02, 0.2, and 2.0 mg/kg) in WT mice results in a significant increase in CBF, but this effect of this treatment is absent in DP1−/− mice. BW245C attenuates functional deficits after stroke. BW245C significantly reverses these conditions that neurologic deficit is significantly augmented, whereas locomotor activity is significantly reduced after stroke in WT mice. BW245C (0.2 mg/kg) injection 1 h after stroke results in a significant decrease in brain infarction in WT mice, whereas the effect of this treatment is not observed in DP1−/− mice. BW245C improves CBF during and after stroke. BW245C results in significantly prolonged bleeding compared with the vehicle-treated group[1]. BW 245C (100 nM) does not significantly increase MBP-positive eosinophils in esophageal epithelium in OVA-sensitized guinea pigs[2].
Animal Admin	The mice are untreated or given an i.p. injection of the vehicle (1% DMSO) or 0.2-mg/kg BW245C. Thirty minutes after the injection, the mice are anesthetized and placed on a thermoregulated pad to maintain body temperature, and 3 mm of the tail tip is excised. The tail is immediately dipped in warm PBS (37.0±0.5°C) and time to visible cessation of bleeding is recorded.
References	[1]. Ahmad AS, et al. PGD₂ DP1 receptor stimulation following stroke ameliorates cerebral blood flow and outcomes. Neuroscience. 2014 Oct 24;279:260-8. [2]. Zhang S, et al. Prostaglandin D₂ receptor D-type prostanoid receptor 2 mediates eosinophil trafficking into the esophagus. Dis Esophagus. 2014 Aug;27(6):601-6. [3]. Ayabe S, et al. Prostaglandin D₂ inhibits collagen secretion from lung fibroblasts by activating the DP receptor. J Pharmacol Sci. 2013;121(4):312-7. Epub 2013 Mar 29. [4]. Kobayashi K, et al. Prostaglandin D₂-DP signaling promotes endothelial barrier function via the cAMP/PKA/Tiam1/Rac1 pathway. Arterioscler Thromb Vasc Biol. 2013 Mar;33(3):565-71.

Density	1.2±0.1 g/cm3
Molecular Formula	C₁₉H₃₂N₂O₅
Molecular Weight	368.468
Exact Mass	368.231110
PSA	106.94000
LogP	2.12
Index of Refraction	1.521

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WGK Germany	3