1026785-55-6

1026785-55-6 structure

Name: VX-222
Chemical Name: 5-(3,3-dimethylbut-1-ynyl)-3-[(4-hydroxycyclohexyl)-(4-methylcyclohexanecarbonyl)amino]thiophene-2-carboxylic acid
CAS Number: 1026785-55-6
Molecular Formula: C₂₅H₃₅NO₄S
Molecular Weight: 445.615
Create Date: 2017-05-22 00:51:23
Modify Date: 2025-08-27 14:20:19

Name	5-(3,3-dimethylbut-1-ynyl)-3-[(4-hydroxycyclohexyl)-(4-methylcyclohexanecarbonyl)amino]thiophene-2-carboxylic acid
Synonyms	5-(3,3-Dimethyl-1-butyn-1-yl)-3-{(trans-4-hydroxycyclohexyl)[(trans-4-methylcyclohexyl)carbonyl]amino}-2-thiophenecarboxylic acid VX222 VCH222 5-(3,3-dimethylbut-1-ynyl)-3-[(trans-4-hydroxycyclohexyl)-(4-trans-methylcyclohexanecarbonyl)amino]thiophene-2-carboxylic acid 5-(3,3-dimethylbut-1-ynyl)-3-((1r,4r)-N-(4-hydroxycyclohexyl)-4-methylcyclohexanecarboxamido)thiophene-2-carboxylic acid 2-Thiophenecarboxylic acid, 5-(3,3-dimethyl-1-butyn-1-yl)-3-[(trans-4-hydroxycyclohexyl)[(trans-4-methylcyclohexyl)carbonyl]amino]- 5-(3,3-dimethylbut-1-ynyl)-3-{(trans-4-hydroxycyclohexyl)[(trans-4-methylcyclohexyl)carbonyl]amino}thiophene-2-carboxylic acid VX-222 VX-222 (VCH-222,Lomibuvir) 5-(3,3-dimethylbut-1-ynyl)-3-[(trans-4-hydroxycyclohexyl)-(trans-4-methylcyclohexanecarbonyl)amino]thiophene-2-carboxylic acid Lomibuvir

Density	1.2±0.1 g/cm3
Boiling Point	640.5±55.0 °C at 760 mmHg
Molecular Formula	C₂₅H₃₅NO₄S
Molecular Weight	445.615
Flash Point	341.2±31.5 °C
Exact Mass	445.228668
PSA	106.08000
LogP	5.15
Vapour Pressure	0.0±2.0 mmHg at 25°C
Index of Refraction	1.589

1026785-63-6

~78%

1026785-55-6

Literature: Lazerwith, Scott E.; Lew, Willard; Zhang, Jennifer; Morganelli, Philip; Liu, Qi; Canales, Eda; Clarke, Michael O.; Doerffler, Edward; Byun, Daniel; Mertzman, Michael; Ye, Hong; Chong, Lee; Xu, Lianhong; Appleby, Todd; Chen, Xiaowu; Fenaux, Martijn; Hashash, Ahmad; Leavitt, Stephanie A.; Mabery, Eric; Matles, Mike; Mwangi, Judy W.; Tian, Yang; Lee, Yu-Jen; Zhang, Jingyu; Zhu, Christine; Murray, Bernard P.; Watkins, William J. Journal of Medicinal Chemistry, 2014 , vol. 57, # 5 p. 1893 - 1901

934-67-8

1026785-55-6

55930-23-9

1026785-55-6

1026785-65-8

1026785-55-6

22288-78-4

1026785-55-6

4746-97-8

1026785-55-6

914780-25-9

1026785-55-6

Precursor 5
1026785-63-6 934-67-8 55930-23-9 22288-78-4
4746-97-8
DownStream 0

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