80456-55-9
80456-55-9 structure
- Name: Vibunazole
- Chemical Name: 1-(4-Chlorophenoxy)-3,3-dimethyl-2-(1H-1,2,4-triazol-1-ylmethyl)- 2-butanol
- CAS Number: 80456-55-9
- Molecular Formula: C15H20ClN3O2
- Molecular Weight: 309.79100
- Catalog: Signaling Pathways Anti-infection Fungal
- Create Date: 2016-10-28 07:17:30
- Modify Date: 2024-01-07 19:15:19
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Vibunazole is a new antifungal azole.
| Name | 1-(4-Chlorophenoxy)-3,3-dimethyl-2-(1H-1,2,4-triazol-1-ylmethyl)- 2-butanol |
|---|---|
| Synonyms |
1 (4 chlorophenoxy) 3,3 dimethyl 2 (1,2,4 triazol 1 yl)methyl 2 butanol
1-Propanone,1-(3,4-dimethoxyphenyl)-3-(dimethylamino)-,hydrochloride 1-(4-chlorophenoxy)-3,3-dimethyl-2-(1,2,4-triazol-1-yl-methyl)-butan-2-ol 2-(4-chlorophenoxymethyl)-3,3-dimethyl-1-(1,2,4-triazol-1-yl)-2-butanol 1-(3,4-dimethoxyphenyl)-3-(dimethylamino)propan-1-one hydrochloride(1:1) 1,2-dimethoxy-4-(3-dimethylaminopropionyl)benzene hydrochloride 1-(3,4-dimethoxy-phenyl)-3-dimethylamino-propan-1-one,hydrochloride 3-(3,4-dimethoxyphenyl)-N,N-dimethyl-3-oxo-1-propanamine hydrochloride 4-(3-dimethylaminopropionyl)-1,2-dimethoxybenzene hydrochloride 2-(4-chlorophenoxy)-methyl-3,3-dimethyl-1-(1,2,4-triazol-1-yl)-butan-2-ol 1-(3,4-Dimethoxy-phenyl)-3-dimethylamino-propan-1-on,Hydrochlorid 1-(3,4-Dimethoxyphenyl)-3-(dimethylamino)-1-propanone hydrochloride Vibunazole |
| Description | Vibunazole is a new antifungal azole. |
|---|---|
| Related Catalog | |
| In Vitro | Vibunazole is an antifungal azole. Low concentrations of all three drugs inhibit Coccidioides immitis, strain Silveira, in vitro with a descending order of activity ketoconazole>Vibunazole>BAY 1 9139[1]. |
| In Vivo | The untreated, infected mice lost weight initially and progressively, whereas treated mice gain weight after an initial loss with Vibunazole (all doses), BAY 1 9139 and ketoconazole at 2.5 mg/kg/day. With both Vibunazole and BAY 1 9139, the 5 and 10 mg/kg doses yield serum concentrations exceeding the MICs for the Coccidioides immitis test strain (0.8 and 1.5 μg/mL respectively) for periods in excess of 30 min after injection[1]. |
| Animal Admin | Under pentobarbital anesthesia 26 to 30 g female Swiss-Webster albino mice are injected intratracheally with either 0.05 mL sterile 0.9 % NaCI solution or 150 arthroconidia of Coccidioides imrnitis (strain Silveira) suspended in 0.05 mL of 0.9 % NaCI solution. Treatment of cohorts of ten infected and ten uninfected mice is begun 72 h after inoculation. Daily i.v. injections (tail vein) of 0.1 mL of 5 % glucose solution delivering either 0, 2.5, 5 or 10 mg/kg/dose of Vibunazole are given for 30 days[1]. |
| References |
| Density | 1.19g/cm3 |
|---|---|
| Boiling Point | 486.3ºC at 760 mmHg |
| Molecular Formula | C15H20ClN3O2 |
| Molecular Weight | 309.79100 |
| Flash Point | 247.9ºC |
| Exact Mass | 309.12400 |
| PSA | 60.17000 |
| LogP | 2.78770 |
| Index of Refraction | 1.563 |
| Storage condition | 2-8℃ |
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80456-55-9 |
| Literature: Bayer Aktiengesellschaft Patent: US4652579 A1, 1987 ; |
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80456-55-9 |
| Literature: Bayer Aktiengesellschaft Patent: US4886892 A1, 1989 ; |
