931695-79-3
931695-79-3 structure
- Name: ML-191
- Chemical Name: 3-(1-{[1-(4-Methylphenyl)cyclopropyl]carbonyl}-4-piperidinyl)-5-p henyl-1,3,4-oxadiazol-2(3H)-one
- CAS Number: 931695-79-3
- Molecular Formula: C24H25N3O3
- Molecular Weight: 403.474
- Catalog: Signaling Pathways GPCR/G Protein GPR55
- Create Date: 2016-09-23 19:44:07
- Modify Date: 2025-08-20 17:07:30
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ML-191 is an antagonist of GPR55. It inhibits GPR55 signaling induced by lysophosphatidylinositol (EC50=1.076 µM in U2OS cells overexpressing GPR55). ML-191 inhibits LPI-induced phosphorylation of ERK1/2 (IC50=328 nM) and receptor-dependent translocation of PKCβII when used at a concentration of 30 µM[1].
| Name | 3-(1-{[1-(4-Methylphenyl)cyclopropyl]carbonyl}-4-piperidinyl)-5-p henyl-1,3,4-oxadiazol-2(3H)-one |
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| Synonyms |
3-(1-{[1-(4-Methylphenyl)cyclopropyl]carbonyl}-4-piperidinyl)-5-phenyl-1,3,4-oxadiazol-2(3H)-one
1,3,4-Oxadiazol-2(3H)-one, 3-[1-[[1-(4-methylphenyl)cyclopropyl]carbonyl]-4-piperidinyl]-5-phenyl- |
| Description | ML-191 is an antagonist of GPR55. It inhibits GPR55 signaling induced by lysophosphatidylinositol (EC50=1.076 µM in U2OS cells overexpressing GPR55). ML-191 inhibits LPI-induced phosphorylation of ERK1/2 (IC50=328 nM) and receptor-dependent translocation of PKCβII when used at a concentration of 30 µM[1]. |
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| Related Catalog | |
| References |
[1]. Heynen-Genel S, et al. Screening for Selective Ligands for GPR55 - Antagonists. 2010 Oct 30 |
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 569.5±60.0 °C at 760 mmHg |
| Molecular Formula | C24H25N3O3 |
| Molecular Weight | 403.474 |
| Flash Point | 298.2±32.9 °C |
| Exact Mass | 403.189606 |
| PSA | 68.34000 |
| LogP | 2.75 |
| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
| Index of Refraction | 1.668 |