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  • DC Chemicals Limited
  • China
  • Product Name: TNP-351
  • Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
  • Purity: 98.0%
  • Stocking Period: 3 Day
  • Contact: Tony Cao

125991-51-7

125991-51-7 structure
125991-51-7 structure
  • Name: TNP-351
  • Chemical Name: (2S)-2-[[4-[3-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)propyl]benzoyl]amino]pentanedioic acid
  • CAS Number: 125991-51-7
  • Molecular Formula: C21H24N6O5
  • Molecular Weight: 440.45200
  • Catalog: Signaling Pathways Cell Cycle/DNA Damage Antifolate
  • Create Date: 2017-10-26 17:52:57
  • Modify Date: 2024-01-16 18:01:10
  • TNP-351 is an antifolate. TNP-351, a dihydrofolate reductase (DHFR) inhibitor, has potent antitumor activity against not only leukemia cells but also solid tumor cells in vitro and in vivo[1].

Name (2S)-2-[[4-[3-(2,4-diamino-7H-pyrrolo[2,3-d]pyrimidin-5-yl)propyl]benzoyl]amino]pentanedioic acid
Synonyms Tnp 351
N-(4-(3-(2,4-Diamino-1H-pyrrolo(2,3-d)pyrimidin-5-yl)propyl)benzoyl)-L-glutamic acid
Description TNP-351 is an antifolate. TNP-351, a dihydrofolate reductase (DHFR) inhibitor, has potent antitumor activity against not only leukemia cells but also solid tumor cells in vitro and in vivo[1].
Related Catalog
Target

Antifolate, DHFR[1]

In Vitro TNP-351 inhibits the proliferation of mouse L1210 leukemia cells and human CCRF-CEM lymphoblastic leukemia cells with ED50 values of 0.79 and 2.7 nM, respectively[1]. The ED50 values determined for the parent cell line CCRF-CEM, CCRFCEM R30/6 subline, CCRF-CEM R1, and CCRF-CEM R2 are 2.7, 5.8, 94 and 76 nM, respectively[1]. Cell Viability Assay[1] Cell Line: L1210 and CCRF-CEM cells Concentration: 0.1, 0.3, 1, 3, and 10 nM for L1210 cells; 0.3, 1, 3, 10, and 30 for CCRF-CEM cells Incubation Time: 48 hours for L1210 cells; 72 hours for CCRF-CEM cells Result: The ED50 values were 0.79 and 2.7 nM for L1210 and CCRF-CEM cells, respectively.
References

[1]. F Itoh ,et al. Novel pyrrolo[2,3-d]pyrimidine Antifolate TNP-351: Cytotoxic Effect on Methotrexate-Resistant CCRF-CEM Cells and Inhibition of Transformylases of De Novo Purine Biosynthesis. Cancer Chemother Pharmacol. 1994;34(4):273-9.

Density 1.473g/cm3
Molecular Formula C21H24N6O5
Molecular Weight 440.45200
Exact Mass 440.18100
PSA 198.04000
LogP 2.24760
Index of Refraction 1.712