177172-49-5

177172-49-5 structure

Name: R 568 hydrochloride
Chemical Name: 3-(2-chlorophenyl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]propan-1-amine,hydrochloride
CAS Number: 177172-49-5
Molecular Formula: C₁₈H₂₃Cl₂NO
Molecular Weight: 340.28700
Catalog: Signaling Pathways GPCR/G Protein CaSR
Create Date: 2017-10-02 19:51:34
Modify Date: 2024-01-07 11:06:52
Tecalcet Hydrochloride (R 568 Hydrochloride), an orally active calcimimetic compound, allosterically and positively modulates the calcium-sensing receptor (CaSR). Tecalcet Hydrochloride (R 568 Hydrochloride) increases the sensitivity to activation by extracellular Ca2+[1][2][3].

Name	3-(2-chlorophenyl)-N-[(1R)-1-(3-methoxyphenyl)ethyl]propan-1-amine,hydrochloride
Synonyms	Norcalcin R-568 Tecalcet hydrochloride KRN-568 NPS R-568 Tecalcet HCl

Description	Tecalcet Hydrochloride (R 568 Hydrochloride), an orally active calcimimetic compound, allosterically and positively modulates the calcium-sensing receptor (CaSR). Tecalcet Hydrochloride (R 568 Hydrochloride) increases the sensitivity to activation by extracellular Ca2+[1][2][3].
Related Catalog	Research Areas >> Others Signaling Pathways >> GPCR/G Protein >> CaSR
References	[1]. Wada, M., et al. The calcimimetic compound NPS R-568 suppresses parathyroid cell proliferation in rats with renal insufficiency. Control of parathyroid cell growth via a calcium receptor. Journal of Clinical Investigation 100(12), 2977-2983 (1997). [2]. Nemeth, E.F., et al. The parathyroid calcium receptor: a novel therapeutic target for treating hyperparathyroidism. Pediatr.Nephrol. 10(3), 275-279 (1996). [3]. Nemeth, E.F., et al. Calcimimetics with potent and selective activity on the parathyroid calcium receptor. Proceedings of the National Academy of Sciences of the United States of America 95(7), 4040-4045 (1998).