851546-61-7
851546-61-7 structure
- Name: PSI-697
- Chemical Name: 2-[(4-chlorophenyl)methyl]-3-hydroxy-7,8,9,10-tetrahydrobenzo[h]quinoline-4-carboxylic acid
- CAS Number: 851546-61-7
- Molecular Formula: C21H18ClNO3
- Molecular Weight: 367.82600
- Catalog: Research Areas Cancer
- Create Date: 2016-02-09 08:13:32
- Modify Date: 2024-01-06 17:19:10
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PSI-697is a P-selectin inhibitor.In vivo: 30 mg/kg; oral gavage daily. Animals treaed with PSI-697 shows a significantly decreased intimal thickness score when compared with vehicle control IVCs. PSI-697 significantly decreased vein wall levels of platelet-derived growth factor . d PSI-697 inhibits vein wall injury independently of thrombus mass. P-selectin inhibition seemed superior to LMWH in measured parameters of injury and mediator inhibition. PSI-697 inhibit vein wall injury independently of thrombus size in a rodent model of DVT. [1] PSI-697 (50 mg/kg p.o.) significantly reduced the number of rolling leukocytes by 39% (P < 0.05) versus vehicle control. In a rat venous thrombosis model, PSI-697 (100 mg/kg p.o.) reduced thrombus weight by 18% (P < 0.05) relative to vehicle, without prolonging bleeding time. [2] Animals receiving PSI-697 demonstrated significantly increased plasma D-dimer levels versus LMWH and control animals six hours post thrombus induction.[3]
| Name | 2-[(4-chlorophenyl)methyl]-3-hydroxy-7,8,9,10-tetrahydrobenzo[h]quinoline-4-carboxylic acid |
|---|---|
| Synonyms |
2-(4-Chloro-benzyl)-3-hydroxy-7,8,9,10-tetrahydro-benzo[h]quinoline-4-carboxylic acid
UNII-LH1XC916ME PSI-697 |
| Description | PSI-697is a P-selectin inhibitor.In vivo: 30 mg/kg; oral gavage daily. Animals treaed with PSI-697 shows a significantly decreased intimal thickness score when compared with vehicle control IVCs. PSI-697 significantly decreased vein wall levels of platelet-derived growth factor . d PSI-697 inhibits vein wall injury independently of thrombus mass. P-selectin inhibition seemed superior to LMWH in measured parameters of injury and mediator inhibition. PSI-697 inhibit vein wall injury independently of thrombus size in a rodent model of DVT. [1] PSI-697 (50 mg/kg p.o.) significantly reduced the number of rolling leukocytes by 39% (P < 0.05) versus vehicle control. In a rat venous thrombosis model, PSI-697 (100 mg/kg p.o.) reduced thrombus weight by 18% (P < 0.05) relative to vehicle, without prolonging bleeding time. [2] Animals receiving PSI-697 demonstrated significantly increased plasma D-dimer levels versus LMWH and control animals six hours post thrombus induction.[3] |
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| Related Catalog | |
| References |
| Molecular Formula | C21H18ClNO3 |
|---|---|
| Molecular Weight | 367.82600 |
| Exact Mass | 367.09800 |
| PSA | 70.42000 |
| LogP | 4.76160 |
| Storage condition | 2-8℃ |
|
~39%
851546-61-7 |
| Literature: Wang, Youchu Patent: US2007/82923 A1, 2007 ; Location in patent: Page/Page column 12 ; |
|
~%
851546-61-7 |
| Literature: Wyeth Patent: US2005/101569 A1, 2005 ; Location in patent: Page/Page column 14 ; |
|
~41%
851546-61-7 |
| Literature: Kaila, Neelu; Janz, Kristin; Huang, Adrian; Moretto, Alessandro; DeBernardo, Silvano; Bedard, Patricia W.; Tam, Steve; Clerin, Valerie; Keith Jr., James C.; Tsao, Desiree H.H.; Sushkova, Natalia; Shaw, Gray D.; Camphausen, Raymond T.; Schaub, Robert G.; Wang, Qin Journal of Medicinal Chemistry, 2007 , vol. 50, # 1 p. 40 - 64 |
|
~%
851546-61-7 |
| Literature: Kaila, Neelu; Janz, Kristin; Huang, Adrian; Moretto, Alessandro; DeBernardo, Silvano; Bedard, Patricia W.; Tam, Steve; Clerin, Valerie; Keith Jr., James C.; Tsao, Desiree H.H.; Sushkova, Natalia; Shaw, Gray D.; Camphausen, Raymond T.; Schaub, Robert G.; Wang, Qin Journal of Medicinal Chemistry, 2007 , vol. 50, # 1 p. 40 - 64 |
|
~%
851546-61-7 |
| Literature: Kaila, Neelu; Janz, Kristin; Huang, Adrian; Moretto, Alessandro; DeBernardo, Silvano; Bedard, Patricia W.; Tam, Steve; Clerin, Valerie; Keith Jr., James C.; Tsao, Desiree H.H.; Sushkova, Natalia; Shaw, Gray D.; Camphausen, Raymond T.; Schaub, Robert G.; Wang, Qin Journal of Medicinal Chemistry, 2007 , vol. 50, # 1 p. 40 - 64 |
|
~%
851546-61-7 |
| Literature: Kaila, Neelu; Janz, Kristin; Huang, Adrian; Moretto, Alessandro; DeBernardo, Silvano; Bedard, Patricia W.; Tam, Steve; Clerin, Valerie; Keith Jr., James C.; Tsao, Desiree H.H.; Sushkova, Natalia; Shaw, Gray D.; Camphausen, Raymond T.; Schaub, Robert G.; Wang, Qin Journal of Medicinal Chemistry, 2007 , vol. 50, # 1 p. 40 - 64 |
