40709-76-0

40709-76-0 structure

Name: RX 67668
Chemical Name: 1-[(1R,2R)-2-phenylcyclohexyl]pyrrolidine,hydrochloride
CAS Number: 40709-76-0
Molecular Formula: C₁₆H₂₄ClN
Molecular Weight: 265.82100
Catalog: Signaling Pathways Neuronal Signaling AChE
Create Date: 2016-08-31 09:49:57
Modify Date: 2024-01-12 09:38:38
RX 67668 is a potent cholinesterase inhibitor with an IC50 of 5 μM for both acetylcholinesterase (AChE) and butyrylcholinesterase. RX 67668 can reverse the neuromuscular blockade induced by D-tubocurarine. RX 67668 is a muscle relaxant used to relieve skeletal muscle fatigue[1][2].

Name	1-[(1R,2R)-2-phenylcyclohexyl]pyrrolidine,hydrochloride

Description	RX 67668 is a potent cholinesterase inhibitor with an IC50 of 5 μM for both acetylcholinesterase (AChE) and butyrylcholinesterase. RX 67668 can reverse the neuromuscular blockade induced by D-tubocurarine. RX 67668 is a muscle relaxant used to relieve skeletal muscle fatigue[1][2].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> AChE
Target	IC50: 5 μM (acetylcholinesterase) and 5 μM (butyrylcholinesterase)[1]
In Vivo	RX 67668 (1-4 mg/kg; i.p.) reduces by half the dose of methacholine necessary to produce red tears, whilst RX 67668 (7-2 mg/kg s.c.) is necessary to reduce the pupil diameter of the mouse to 50% of the control value[1]. Rat anterior tibialis preparation of the cat tibialis preparation demonstrates that RX 67668 (0.3-1.0 mg/kg; i.v.) is effective in reversing tubocurarine-induced muscle blockade[1].
References	[1]. Doxey JC, et al. Some pharmacological properties of RX 67668--a new anticholinesterase. Br J Pharmacol. 1972 Nov;46(3):568P-569P. [2]. Metcalf G, wt al. Evaluation of RX 72601 as an anti-curare agent. Br J Anaesth. 1975 Apr;47(4):451-6.