1263045-16-4

1263045-16-4 structure

Name: Mal-amido-PEG4-acid
Chemical Name: NHS-PEG4-Maleimide
CAS Number: 1263045-16-4
Molecular Formula: C₁₈H₂₈N₂O₉
Molecular Weight: 416.42300
Catalog: Signaling Pathways PROTAC PROTAC Linker
Create Date: 2017-12-26 16:57:46
Modify Date: 2024-01-17 13:23:50
Mal-amido-PEG4-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Name	NHS-PEG4-Maleimide
Synonyms	19-Maleimido-17-oxo-4,7,10,13-tetraoxa-16-azanonadecanoic Acid Mal-Amido-PEG4-acid MAL-PEG4-CH2CH2COOH

Description	Mal-amido-PEG4-C2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.