Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Peptide T?
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: ALA-SER-THR-THR-THR-ASN-TYR-THR ACETATE
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Taiwan Oyi peptide Co. Ltd
China
Product Name: Peptide T
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106362-32-7

106362-32-7 structure

106362-32-7 structure

Name: Peptide T
Chemical Name: peptide T
CAS Number: 106362-32-7
Molecular Formula: C₃₅H₅₅N₉O₁₆
Molecular Weight: 857.86200
Catalog: Peptides
Create Date: 2017-01-24 15:56:56
Modify Date: 2024-01-02 13:28:40
Peptide T is an octapeptide from the V2 region of HIV-1 gp120. Peptide T is a ligand for the CD4 receptor and prevents binding of HIV to the CD4 receptor.

Name	peptide T
Synonyms	Ala-Ser-Thr-Thr-Thr-Asn-Tyr-Thr

Description	Peptide T is an octapeptide from the V2 region of HIV-1 gp120. Peptide T is a ligand for the CD4 receptor and prevents binding of HIV to the CD4 receptor.
Related Catalog	Signaling Pathways >> Anti-infection >> HIV Peptides Research Areas >> Infection
Target	CD4, HIV[1]
In Vitro	Peptide T acts to block viral entry as it inhibits in the MAGI cell assay and blocks infection in the luciferase reporter assay using HIV virions pseudotyped with ADA envelope. Peptide T selectively inhibits HIV replication using chemokine receptor CCR5 compared to CXC4[2]. Peptide T at 10-8 M induces IL-10 production by the human Th2 cell line and PBMC. Also peptide T at 10-9 M concentration significantly inhibits IFN-g production by PBMC[3].
In Vivo	Peptide T is administered subcutaneously at different doses and phases of the experimental autoimmune encephalomyelitis (EAE) disease, but Peptide T neither prevents nor ameliorates EAE[4].
Cell Assay	Peripheral blood mononuclear cells are stimulated with PHA (5 mg/mL) along with various concentrations of peptide T (10-6-10-12 M) for 48 h at 37°C. Supernatants are collected and frozen until analysis[3].
Animal Admin	Rats[4] Peptide T (125, 250, 500, 800 μg) is randomly given subcutaneously to Female Lewis rats aged 6-8 weeks in the hind foot flanks in a final volume of 0.2 mL. Control animals receive the same volume of saline alone[4].
References	[1]. Ruff MR, et al. Peptide T[4-8] is core HIV envelope sequence required for CD4 receptor attachment. Lancet. 1987 Sep 26;2(8561):751. [2]. Ruff MR, et al. Peptide T inhibits HIV-1 infection mediated by the chemokine receptor-5 (CCR5). Antiviral Res. 2001 Oct;52(1):63-75. [3]. Raychaudhuri SP, et al. Immunomodulatory effects of peptide T on Th 1/Th 2 cytokines. Int J Immunopharmacol. 1999 Sep;21(9):609-15. [4]. Sáez-Torres I, et al. Peptide T does not ameliorate experimental autoimmune encephalomyelitis (EAE) in Lewis rats. Clin Exp Immunol. 2000 Jul;121(1):151-6.

Molecular Formula	C₃₅H₅₅N₉O₁₆
Molecular Weight	857.86200
Exact Mass	857.37700
PSA	431.49000
Vapour Pressure	0mmHg at 25°C
Storage condition	2-8℃