862772-11-0

862772-11-0 structure

Name: Cyclo(-Arg-Gly-Asp-D-Phe-Cys) acetate salt
Chemical Name: Cyclo(L-arginylglycyl-L-α-aspartyl-D-phenylalanyl-L-cysteinyl)
CAS Number: 862772-11-0
Molecular Formula: C₂₄H₃₄N₈O₇S
Molecular Weight: 578.64100
Catalog: Signaling Pathways Cytoskeleton Integrin
Create Date: 2016-11-12 00:43:14
Modify Date: 2024-01-13 13:52:32
Cyclo(Arg-Gly-Asp-D-Phe-Cys) (Cyclo RGDfC) is a cyclic RGD peptide which has high affinity to αvβ3. Cyclo(Arg-Gly-Asp-D-Phe-Cys) can be used in the research of tumors[1].

Name	Cyclo(L-arginylglycyl-L-α-aspartyl-D-phenylalanyl-L-cysteinyl)
Synonyms	cyclo (Arg-Gly-Asp-d-Phe-Cys) CYCLO(ARG-GLY-ASP-D-PHE-CYS)ACETATE SALT cyclo(Arg-Gly-Asp-d-Phe-Cys) Cyclo(-RGDfC), avb3 Integrin Binding Cyclic RGD Peptide CYCLO(-ARG-GLY-ASP-D-PHE-CYS)

Description	Cyclo(Arg-Gly-Asp-D-Phe-Cys) (Cyclo RGDfC) is a cyclic RGD peptide which has high affinity to αvβ3. Cyclo(Arg-Gly-Asp-D-Phe-Cys) can be used in the research of tumors[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cytoskeleton >> Integrin
Target	αvβ3
In Vitro	Cyclo(Arg-Gly-Asp-D-Phe-Cys) (0.5 mM, 24 h) down-regulates the transcription factors Oct 4, Sox 2 and Nanog of mESCs[1]. Cyclo(Arg-Gly-Asp-D-Phe-Cys) (0.5 mM) inhibits integrin gene expression mESC-col I (type I collagen) constructs[1]. Cyclo(Arg-Gly-Asp-D-Phe-Cys) (0.5 mM)-treated mESCs leads to the formation of aggregates and detachment from the surface[1]. RT-PCR[1] Cell Line: MESCs Concentration: 0.5 mM Incubation Time: 24 h Result: Down-regulated Oct 4, Nanog, Sox 2 by 99%, 97.5%, and 90% respectively. Up-regulated Rex1 gene expression.
In Vivo	Cyclo(Arg-Gly-Asp-D-Phe-Cys) (0.5 mM, 24 h)-treated mESCs in the presence/absence of LIF (injected in both thighs) generated teratomas in severe combined immunodeficiency (SCID) mice, which indicates that the process of mESC tumor formation in vivo is dependent on integrin interaction[1].