106449-56-3

106449-56-3 structure

Name: 2'-Deoxyisoguanosine
Chemical Name: 6-amino-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-purin-2-one
CAS Number: 106449-56-3
Molecular Formula: C₁₀H₁₃N₅O₄
Molecular Weight: 267.24
Catalog: Signaling Pathways Cell Cycle/DNA Damage Nucleoside Antimetabolite/Analog
Create Date: 2018-08-19 15:35:14
Modify Date: 2025-08-25 15:53:22
2'-Deoxyisoguanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Name	6-amino-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-purin-2-one
Synonyms	Adenosine,1,2-dihydro-2'-deoxy-2-oxo 2-Hydroxydeoxyadenosine 1,2-Dihydro-2'-deoxy-2-oxoadenosine Deoxyisoguanosine 2'-Deoxyisoguanosine

Description	2'-Deoxyisoguanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
References	[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.

4546-70-7

~80%

106449-56-3

Literature: Helvetica Chimica Acta, , vol. 81, # 5 p. 793 - 811

4291-63-8

~53%

106449-56-3

Literature: Helvetica Chimica Acta, , vol. 74, # 8 p. 1742 - 1748

89178-21-2

~53%

106449-56-3

Literature: Helvetica Chimica Acta, , vol. 74, # 8 p. 1742 - 1748

961-07-9

106449-56-3

Literature: Helvetica Chimica Acta, , vol. 77, # 3 p. 622 - 630

133349-83-4

4461-33-0

106449-56-3

Literature: Helvetica Chimica Acta, , vol. 74, # 8 p. 1742 - 1748

4291-63-8

961-07-9

106449-56-3

Literature: Pharmazie, , vol. 58, # 2 p. 122 - 124