106449-56-3

106449-56-3 structure

Name: 2'-Deoxyisoguanosine
Chemical Name: 6-amino-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-purin-2-one
CAS Number: 106449-56-3
Molecular Formula: C₁₀H₁₃N₅O₄
Molecular Weight: 267.24
Catalog: Signaling Pathways Cell Cycle/DNA Damage Nucleoside Antimetabolite/Analog
Create Date: 2018-08-19 15:35:14
Modify Date: 2024-01-12 16:46:21
2'-Deoxyisoguanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

Name	6-amino-9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-purin-2-one
Synonyms	Adenosine,1,2-dihydro-2'-deoxy-2-oxo 2-Hydroxydeoxyadenosine 1,2-Dihydro-2'-deoxy-2-oxoadenosine Deoxyisoguanosine 2'-Deoxyisoguanosine

Description	2'-Deoxyisoguanosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Cell Cycle/DNA Damage >> Nucleoside Antimetabolite/Analog
References	[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.