273203-62-6

273203-62-6 structure

Name: Myristyl nicotinate
Chemical Name: tetradecyl pyridine-3-carboxylate
CAS Number: 273203-62-6
Molecular Formula: C₂₀H₃₃NO₂
Molecular Weight: 319.48200
Catalog: Research Areas Cancer
Create Date: 2018-08-07 23:09:08
Modify Date: 2024-01-09 11:33:36
Myristyl nicotinate (Tetradecyl nicotinate) is an ester prodrug and a lipophilic derivative of Nicotinic acid. Myristyl nicotinate is being developed for delivery of Nicotinic acid into the skin for prevention of actinic keratosis and its progression to skin cancer. Myristyl nicotinate shows to stimulate epidermal differentiation in photodamaged skin, increasing skin NAD content and strengthening the skin barrier[1][2].

Name	tetradecyl pyridine-3-carboxylate
Synonyms	myristyl nicotinic acid ester 8QWM6I035C nicotinic acid tetradecyl ester UNII-8QWM6I035C n-tetradecyl nicotinic acid ester MyristylNicotinate Nicotinsaeure-tetradecylester Tetradecyl nicotinate

Description	Myristyl nicotinate (Tetradecyl nicotinate) is an ester prodrug and a lipophilic derivative of Nicotinic acid. Myristyl nicotinate is being developed for delivery of Nicotinic acid into the skin for prevention of actinic keratosis and its progression to skin cancer. Myristyl nicotinate shows to stimulate epidermal differentiation in photodamaged skin, increasing skin NAD content and strengthening the skin barrier[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
In Vitro	Myristyl nicotinate (Tetradecyl nicotinate) is used for treatment and prevention of conditions that involve skin barrier impairment such as chronic photodamage and atopic dermatitis or for mitigating skin barrier impairment that results from therapy such as retinoids or steroids[2].
References	[1]. Catz P, et al. Simultaneous determination of myristyl nicotinate, nicotinic acid, and nicotinamide in rabbit plasma by liquid chromatography-tandem mass spectrometry using methyl ethyl ketone as a deproteinization solvent. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Dec 27;829(1-2):123-35. [2]. Jacobson MK, et al. Effect of myristyl nicotinate on retinoic acid therapy for facial photodamage. Exp Dermatol. 2007 Nov;16(11):927-35.

112-72-1

20260-53-1

273203-62-6

Precursor 2
112-72-1 20260-53-1
DownStream 0