347841-44-5

347841-44-5 structure
347841-44-5 structure
  • Name: (2H9)-9H-Fluoren-2-(2H2)amine
  • Chemical Name: 2-aminofluorene-d11
  • CAS Number: 347841-44-5
  • Molecular Formula: C13D11N
  • Molecular Weight: 192.301
  • Catalog: Signaling Pathways Cell Cycle/DNA Damage DNA/RNA Synthesis
  • Create Date: 2018-08-26 22:11:14
  • Modify Date: 2024-01-06 17:54:10
  • 2-Aminofluorene-d11 is the deuterium labeled 2-Aminofluorene[1]. 2-Aminofluorene is a synthetic chemical insecticide. 2-Aminofluorene is a genotoxin. 2-Aminofluorene can be used in the research of DNA adduct structure, DNA repair, carcinogenesis, and mutagenesis[2][3][4].

Name 2-aminofluorene-d11
Synonyms 9H-Fluoren-d-2-amine-d
(H)-9H-Fluoren-2-(H)amine
Description 2-Aminofluorene-d11 is the deuterium labeled 2-Aminofluorene[1]. 2-Aminofluorene is a synthetic chemical insecticide. 2-Aminofluorene is a genotoxin. 2-Aminofluorene can be used in the research of DNA adduct structure, DNA repair, carcinogenesis, and mutagenesis[2][3][4].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.  

[2]. Heflich RH, et al. Genetic toxicity of 2-acetylaminofluorene, 2-aminofluorene and some of their metabolites and model metabolites. Mutat Res. 1994 Oct;318(2):73-114. ; ;  

[3]. Kim BS, et al. Immunosuppressive effects of 2-acetylaminofluorene and 2-aminofluorene on murine splenocytes culture. Drug Chem Toxicol. 1989 Sep-Dec;12(3-4):297-311.  

[4]. Levy GN, et al. 2-Aminofluorene-DNA adduct formation in acetylator congenic mouse lines. Carcinogenesis. 1989 Apr;10(4):705-9.  

Density 1.2±0.1 g/cm3
Boiling Point 379.3±21.0 °C at 760 mmHg
Molecular Formula C13D11N
Molecular Weight 192.301
Flash Point 204.8±17.4 °C
Exact Mass 192.158188
PSA 26.02000
LogP 2.88
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.697