Shanghai Nianxing Industrial Co., Ltd
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Product Name: Etidocaine
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Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Etidocaine
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36637-18-0

36637-18-0 structure

36637-18-0 structure

Name: etidocaine
Chemical Name: etidocaine
CAS Number: 36637-18-0
Molecular Formula: C₁₇H₂₈N₂O
Molecular Weight: 276.417
Catalog: API Anesthetic Agents Local anesthetics
Create Date: 2018-09-03 11:40:31
Modify Date: 2024-01-11 06:57:10
Etidocaine (EDC) is a long aminoamide local anesthetic[1].

Name	etidocaine
Synonyms	(2S)-N-(2,6-Dimethylphenyl)-2-[ethyl(propyl)amino]butanamide Butanamide, N-(2,6-dimethylphenyl)-2-(ethylpropylamino)-, (2S)- 2-ethylpropylamino-2,6-n-butyroxylidide Etidocaine

Description	Etidocaine (EDC) is a long aminoamide local anesthetic[1].
Related Catalog	Research Areas >> Infection Research Areas >> Others Signaling Pathways >> Others >> Others
In Vitro	IGL-EDC formulations can induce a significant increase in human fibroblasts survival[1]. Cell Viability Assay[1] Cell Line: Human fibroblasts cells Concentration: 0, 4, 8, 16, 24 mM Incubation Time: 4, 6 and 24 h Result: Showed that cell survival decreased in a (EDC) concentration with time-dependent manner.
In Vivo	Etidocaine (spinal injection, 0.0075%, once) does not show postinjection neurologic deficit[2]. Animal Model: Adult Swiss Webster male mice[2] Dosage: 0.0075% Administration: Etidocaine (spinal injection, 0.0075%, once) Result: Did not show postinjection neurologic deficit.
References	[1]. Oliveira, et al. Sustained Release from Ionic-Gradient Liposomes Significantly Decreases ETIDOCAINE Cytotoxicity. Pharmaceutical research vol. 35, 12 229. 10 Oct. 2018. [2]. Langerman, L, et al. The partition coefficient as a predictor of local anesthetic potency for spinal anesthesia: evaluation of five local anesthetics in a mouse model. Anesthesia and analgesia vol. 79,3 (1994): 490-4.

Density	1.0±0.1 g/cm3
Boiling Point	389.7±30.0 °C at 760 mmHg
Molecular Formula	C₁₇H₂₈N₂O
Molecular Weight	276.417
Flash Point	189.5±24.6 °C
Exact Mass	276.220154
PSA	32.34000
LogP	3.77
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.532

CHEMICAL IDENTIFICATION

RTECS NUMBER :: EJ3595000

CHEMICAL NAME :: Butanamide, N-(2,6-dimethylphenyl)-2-(ethylpropylamino)-, (+-)-

CAS REGISTRY NUMBER :: 36637-18-0

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C17-H28-N2-O

MOLECULAR WEIGHT :: 276.47

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 47500 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949- Volume(issue)/page/year: 42,201,1990