220941-93-5
220941-93-5 structure
- Name: CP-226269
- Chemical Name: 5-fluoro-2-[(4-pyridin-2-ylpiperazin-1-yl)methyl]-1H-indole
- CAS Number: 220941-93-5
- Molecular Formula: C18H19FN4
- Molecular Weight: 310.37
- Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
- Create Date: 2018-12-24 15:03:32
- Modify Date: 2025-08-29 11:06:22
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CP 226269 is a potent dopamine D4 receptor agonist that induces calcium flux with EC50 of 32.0 nM. CP 226269 can be used in the research of schizophrenia and other related diseases[1].
| Name | 5-fluoro-2-[(4-pyridin-2-ylpiperazin-1-yl)methyl]-1H-indole |
|---|---|
| Synonyms |
HMS3263O08
5-fluoro-2-(4-pyridin-2-yl-piperazin-1-ylmethyl)-1H-indole 5-fluoro-2-[[4-(2-pyridinyl)-1-piperazinyl]methyl]-1H-indole 5-Fluoro-2-{[4-(2-pyridinyl)-1-piperazinyl]methyl}-1H-indole |
| Description | CP 226269 is a potent dopamine D4 receptor agonist that induces calcium flux with EC50 of 32.0 nM. CP 226269 can be used in the research of schizophrenia and other related diseases[1]. |
|---|---|
| Related Catalog | |
| References |
| Molecular Formula | C18H19FN4 |
|---|---|
| Molecular Weight | 310.37 |
| Exact Mass | 310.15900 |
| PSA | 35.16000 |
| LogP | 3.02710 |
| RIDADR | NONH for all modes of transport |
|---|
|
~82%
220941-93-5 |
| Literature: Cowart, Marlon; Latshaw, Steven P.; Bhatia, Pramila; Daanen, Jerome F.; Rohde, Jeffrey; Nelson, Sherry L.; Patel, Meena; Kolasa, Teodozyi; Nakane, Masaki; Uchic, Marie E.; Miller, Loan N.; Terranova, Marc A.; Chang, Renjie; Donnelly-Roberts, Diana L.; Namovic, Marian T.; Hollingsworth, Peter R.; Martino, Brenda R.; Lynch III, James J.; Sullivan, James P.; Hsieh, Gin C.; Moreland, Robert B.; Brioni, Jorge D.; Stewart, Andrew O. Journal of Medicinal Chemistry, 2004 , vol. 47, # 15 p. 3853 - 3864 |
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220941-93-5 |
| Literature: Journal of Medicinal Chemistry, , vol. 47, # 15 p. 3853 - 3864 |
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220941-93-5 |
| Literature: Journal of Medicinal Chemistry, , vol. 47, # 15 p. 3853 - 3864 |
| Precursor 2 | |
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| DownStream 0 | |