206991-64-2

206991-64-2 structure

Name: PG-11047 tetrahydrochloride
Chemical Name: (2E)-N,N-Bis[3-(ethylamino)propyl]-2-butene-1,4-diamine
CAS Number: 206991-64-2
Molecular Formula: C₁₄H₃₆Cl₄N₄
Molecular Weight: 402.27
Catalog: Research Areas Cancer
Create Date: 2016-02-03 21:11:30
Modify Date: 2024-01-14 17:46:57
PG-11047 (CGC-11047), a polyamine analogue, is a nonfunctional competitor of the natural polyamine spermine. PG-11047 has broad spectrum anticancer activities[1][2].

Name	(2E)-N,N-Bis[3-(ethylamino)propyl]-2-butene-1,4-diamine

Description	PG-11047 (CGC-11047), a polyamine analogue, is a nonfunctional competitor of the natural polyamine spermine. PG-11047 has broad spectrum anticancer activities[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Wen-Lin Kuo, et al. A systems analysis of the chemosensitivity of breast cancer cells to the polyamine analogue PG-11047. BMC Med. 2009 Dec 14;7:77. [2]. Murray Stewart T, et al. A Phase Ib multicenter, dose-escalation study of the polyamine analogue PG-11047 in combination with gemcitabine, docetaxel, bevacizumab, erlotinib, cisplatin, 5-fluorouracil, or sunitinib in patients with advanced solid tumors or lymphoma. Cancer Chemother Pharmacol. 2021 Jan;87(1):135-144.