865783-99-9
865783-99-9 structure
- Name: Briciclib
- Chemical Name: 2-Methoxy-5-({[(E)-2-(2,4,6-trimethoxyphenyl)vinyl]sulfonyl}methy l)phenyl dihydrogen phosphate
- CAS Number: 865783-99-9
- Molecular Formula: C19H23O10PS
- Molecular Weight: 474.419
- Catalog: Signaling Pathways Cell Cycle/DNA Damage Eukaryotic Initiation Factor (eIF)
- Create Date: 2018-05-23 08:00:00
- Modify Date: 2024-01-04 12:17:43
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Briciclib is a water soluble derivative of ON 013100, and has the potential in targeting eIF4E for solid cancers.
| Name | 2-Methoxy-5-({[(E)-2-(2,4,6-trimethoxyphenyl)vinyl]sulfonyl}methy l)phenyl dihydrogen phosphate |
|---|---|
| Synonyms |
2-Methoxy-5-({[(E)-2-(2,4,6-trimethoxyphenyl)vinyl]sulfonyl}methyl)phenyl dihydrogen phosphate
ON 014185 Phenol, 2-methoxy-5-[[[(E)-2-(2,4,6-trimethoxyphenyl)ethenyl]sulfonyl]methyl]-, dihydrogen phosphate Briciclib Phenol, 2-Methoxy-5-[[[(1E)-2-(2,4,6-triMethoxyphenyl)ethenyl]sulfonyl]Methyl]-, 1-(dihydrogen phosphate) |
| Description | Briciclib is a water soluble derivative of ON 013100, and has the potential in targeting eIF4E for solid cancers. |
|---|---|
| Related Catalog | |
| Target |
eIF4E[1] |
| In Vitro | Briciclib has the potential in targeting eIF4E. Briciclib shows inhibitory activity against the proliferation of mantle cell leukemia (EKO-1 and MINO), breast (MCF7 and MDA-MB-231), gastric (AGS), and esophageal (OE19, OE33, and FLO-1) cancer cell lines with GI50s of 9.8-12.2 nM, and with no toxicity on normal endothelial cells. Briciclib dose-dependently reduces the expression of cyclin D1 and c-Myc in breast and MCL cancer cell lines within 8 hours[1]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 762.6±70.0 °C at 760 mmHg |
| Molecular Formula | C19H23O10PS |
| Molecular Weight | 474.419 |
| Flash Point | 415.0±35.7 °C |
| Exact Mass | 474.074951 |
| PSA | 156.01000 |
| LogP | 0.89 |
| Appearance | white solid |
| Vapour Pressure | 0.0±2.7 mmHg at 25°C |
| Index of Refraction | 1.578 |
| Storage condition | -20℃ |