856691-93-5

856691-93-5 structure

Name: CEP-11981
Chemical Name: chembl2010872
CAS Number: 856691-93-5
Molecular Formula: C₂₈H₂₇N₇O
Molecular Weight: 477.56000
Catalog: Signaling Pathways Protein Tyrosine Kinase/RTK FGFR
Create Date: 2017-07-01 16:39:39
Modify Date: 2023-01-16 18:34:05
CEP-11981(ESK981; BOL 303213X) is an orally active tyrosine kinase inhibitor (TKI), which can target TIE2, VEGFR1-3 and FGFR1, and has potential anti-tumor and anti-angiogenic effects[1].

Name	chembl2010872
Synonyms	unii-j8ay0z4cbp

Description	CEP-11981(ESK981; BOL 303213X) is an orally active tyrosine kinase inhibitor (TKI), which can target TIE2, VEGFR1-3 and FGFR1, and has potential anti-tumor and anti-angiogenic effects[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> VEGFR
In Vitro	CEP-11981(1μM, 72 h) 可以显著抑制 RT4 细胞生长[1]。
In Vivo	CEP-11981（2.5 mg/kg、5 mg/kg 或 10 mg/kg，口服强饲法，每天，每周 5 天，持续两周）在 RT4 人 UC 肿瘤小鼠模型中，与对照相比显着抑制了 UC 异种移植物的生长，而小鼠本身重量没有变化[1]。
References	[1]. Weiguo Jian, et al. The angiopoietin-TIE2 pathway is a potential therapeutic target in urothelial carcinoma. Anticancer Res. 2014 Jul;34(7):3377-82.