130465-45-1

130465-45-1 structure

Name: A68930
Chemical Name: 1-(aminomethyl)-3-phenyl-3,4-dihydro-1H-isochromene-5,6-diol
CAS Number: 130465-45-1
Molecular Formula: C₁₆H₁₇NO₃
Molecular Weight: 271.31100
Catalog: Signaling Pathways GPCR/G Protein Dopamine Receptor
Create Date: 2018-06-11 12:44:52
Modify Date: 2024-01-03 22:07:27
A68930, as a dopamine D1 receptor agonist, can be used for the research of bronchiectasis[1].

Name	1-(aminomethyl)-3-phenyl-3,4-dihydro-1H-isochromene-5,6-diol

Description	A68930, as a dopamine D1 receptor agonist, can be used for the research of bronchiectasis[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor
Target	D1 Receptor
In Vitro	A68930 (1 μM; 5-60 minutes; 16HBE14o- or NCI-H292 cells) significantly increases phosphorylation of cAMP response element binding (CREB) protein[1]. A68930 (1 μM; 48 hours; NCI-H292 cells) induces MUC5AC mRNA expression and increases the mRNA data of MUC5AC and MUC5AC protein expression[1]. A68930 (1 μM; 20 minutes; NCI-H292 cells) significantly increases intracellular cAMP levels[1]. Western Blot Analysis[1] Cell Line: 16HBE14o- or NCI-H292 cells Concentration: 1 μM Incubation Time: 5~60 minutes Result: Significantly increased phosphorylation of CREB. RT-PCR[1] Cell Line: NCI-H292 cells Concentration: 1 μM Incubation Time: 48 hours Result: Induced MUC5AC mRNA expression. Immunofluorescence[1] Cell Line: NCI-H292 cells Concentration: 1 μM Incubation Time: 48 hours Result: The mRNA data of MUC5AC, MUC5AC protein expression were increased.
References	[1]. Matsuyama N, et al. The dopamine D1 receptor is expressed and induces CREB phosphorylation and MUC5AC expression in human airway epithelium. Respir Res. 2018;19(1):53. Published 2018 Apr 2.