827591-02-6

827591-02-6 structure

Name: GSK983
Chemical Name: N-[(1R)-6-chloro-2,3,4,9-tetrahydro-1H-carbazol-1-yl]pyridine-2-carboxamide
CAS Number: 827591-02-6
Molecular Formula: C₁₈H₁₆ClN₃O
Molecular Weight: 325.79200
Catalog: Research Areas Infection
Create Date: 2017-09-26 19:53:46
Modify Date: 2023-01-14 19:49:29
GSK983 is a broad-spectrum antiviral agent. GSK983 inhibits the replication of adenovirus-5 (Ad-5) and polyoma virus SV40. GSK983 inhibits the growth of cell lines immortalized by EBV, HTLV1, HPV. GSK983 induces the expression of interferon-stimulated genes[1].

Name	N-[(1R)-6-chloro-2,3,4,9-tetrahydro-1H-carbazol-1-yl]pyridine-2-carboxamide
Synonyms	gsk983

Description	GSK983 is a broad-spectrum antiviral agent. GSK983 inhibits the replication of adenovirus-5 (Ad-5) and polyoma virus SV40. GSK983 inhibits the growth of cell lines immortalized by EBV, HTLV1, HPV. GSK983 induces the expression of interferon-stimulated genes[1].
Related Catalog	Research Areas >> Infection
In Vitro	GSK983 (0-10000 nM; 2 h) 抑制原代人成纤维细胞 (HFF) 中腺病毒 5 (Ad-5) 和 Vero 细胞中多瘤病毒 SV40 的复制，中值效应浓度 (K) 分别为 21 nM、7.5 nM；最大抑制率 (I max) 分别为 99%、88%[1]。 GSK983 (0-10000 nM; 72 h) 抑制通过病毒感染永生化的细胞系的生长，对 IM9 (EBV)，B-LCL 5/2/1 ( EBV), MT4 (HTLV1) 细胞的中值效应浓度 (K) 分别为 16, 14, 7.5 nM[1]. GSK983 (10, 100 nM; 24, 48 h) 在 W12, HKC 细胞中诱导干扰素刺激基因的表达[1]。 RT-PCR[1] Cell Line: W12, HKC cells Concentration: 10, 100 nM Incubation Time: 24, 48 h Result: Induced the expression of interferon-stimulated genes in infected and immortalized cells, increased the gene expression of CSF2, IFIT1 (ISG56), IL6, ISG15, OAS1, OAS2, OASL and TNFSF10 (TRAIL).
References	[1]. Harvey R,et al. GSK983: a novel compound with broad-spectrum antiviral activity. Antiviral Res. 2009 Apr;82(1):1-11.