47326-86-3

47326-86-3 structure

Name: WR99210
Chemical Name: 6,6-dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-1,3,5-triazine-2,4-diamine hydrochloride
CAS Number: 47326-86-3
Molecular Formula: C₁₄H₁₈Cl₃N₅O₂
Molecular Weight: 394.68400
Catalog: Research Areas Others
Create Date: 2017-06-04 22:41:03
Modify Date: 2024-01-01 17:21:15
WR99210 is a effective inhibitor of dihydrofolate reductase (DHFR) with an IC50 of <0.075 nM[1]. WR99210 is effective against the most pyrimethamine-resistant Plasmodium falciparum strains[2].

Name	6,6-dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-1,3,5-triazine-2,4-diamine hydrochloride
Synonyms	1,6-Dihydro-6,6-dimethyl-1-[3-(2,4,5-trichlorophenoxy)propoxy]-1,3,5-triazine-2,4-diamine

Description	WR99210 is a effective inhibitor of dihydrofolate reductase (DHFR) with an IC50 of <0.075 nM[1]. WR99210 is effective against the most pyrimethamine-resistant Plasmodium falciparum strains[2].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
Target	IC50: <0.075 nM (DHFR)[1]
References	[1]. Kiara SM, et al. In vitro activity of antifolate and polymorphism in dihydrofolate reductase of Plasmodium falciparum isolates from the Kenyan coast: emergence of parasites with Ile-164-Leu mutation. Antimicrob Agents Chemother. 2009 Sep;53(9):3793-8. [2]. Hastings MD, et al. Pyrimethamine and WR99210 exert opposing selection on dihydrofolatereductase from Plasmodium vivax. Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):13137-41.

RIDADR	NONH for all modes of transport