76343-94-7

76343-94-7 structure

Name: 2-Thiazolidinone,4-[(1R,4Z,8Z,10S,13R,15R)-15-hydroxy-5,10-dimethyl-3-oxo-2,14-dioxabicyclo[11.3.1]heptadeca-4,8-dien-15-yl]-,(4R)-
Chemical Name: latrunculin B
CAS Number: 76343-94-7
Molecular Formula: C₂₀H₂₉NO₅S
Molecular Weight: 395.51300
Catalog: Signaling Pathways Anti-infection Fungal
Create Date: 2016-11-19 13:09:10
Modify Date: 2024-01-06 17:43:06
Latrunculin B, an antimicrobial marine alkaloid, is an actin polymerization inhibitor. Latrunculin B regulates pulmonary vein electrophysiological characteristics and attenuates stretch-induced arrhythmogenesis[1][2]. Antifungal and antiprotozoal activity.

Name	latrunculin B
Synonyms	LATRUNCULIN B LATRUNCULIN B,LATRUNCULIA MAGNIFICA MFCD00270879 LAT-B LatrunculinBfromLutrunculiamagnifica

Description	Latrunculin B, an antimicrobial marine alkaloid, is an actin polymerization inhibitor. Latrunculin B regulates pulmonary vein electrophysiological characteristics and attenuates stretch-induced arrhythmogenesis[1][2]. Antifungal and antiprotozoal activity.
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal
In Vitro	Latrunculin B displays growth inhibition of HeLa cells with an IC50 value of 1.4 μM[1]. Latrunculin B modulates electrophysiological characteristics and arrhythmogenesis in pulmonary vein cardiomyocytes. Latrunculin B (100 nM) decreases the spontaneous electrical activity by 16±4% in pulmonary vein (PV) preparations. Latrunculin B (100 nM) decreases the late Na+ current, L-type Ca2+ current, Na+/Ca2+ exchanger current, and stretch-activated BKCa current in PV cardiomyocytes. Latrunculin B reduces the transient outward K+ current and ultra-rapid delayed rectifier K+ current, but increases the delayed rectifier K+ current in isolated PV cardiomyocytes. Latrunculin B (100 nM) decreases intracellular Ca2+ transient and sarcoplasmic reticulum Ca2+ content in PV cardiomyocytes. Latrunculin B attenuates stretch-induced increased spontaneous electrical activity and trigger activity[2].
References	[1]. Diaa T A Youssef, et al. Magnificines A and B, Antimicrobial Marine Alkaloids Featuring a Tetrahydrooxazolo[3,2-a]azepine-2,5( 3H,6H)-dione Backbone from the Red Sea Sponge Negombata magnifica. Mar Drugs. 2021 Apr 12;19(4):214. [2]. Yen-Yu Lu, et al. Latrunculin B modulates electrophysiological characteristics and arrhythmogenesis in pulmonary vein cardiomyocytes. Clin Sci (Lond). 2016 May;130(9):721-32.

Molecular Formula	C₂₀H₂₉NO₅S
Molecular Weight	395.51300
Exact Mass	395.17700
PSA	110.16000
LogP	3.63220
Storage condition	20°C

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR	NONH for all modes of transport

Precursor 5
105917-28-0 646994-44-7 646994-43-6 101860-51-9
646994-46-9
DownStream 1
76376-32-4

56-41-7	108-65-6
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141-78-6	1310-73-2
13463-67-7	1333-86-4