512-85-6

512-85-6 structure
512-85-6 structure
  • Name: Ascaridole
  • Chemical Name: ascaridole
  • CAS Number: 512-85-6
  • Molecular Formula: C10H16O2
  • Molecular Weight: 168.23
  • Catalog: Research Areas Cardiovascular Disease
  • Create Date: 2018-07-08 18:05:35
  • Modify Date: 2024-01-08 22:12:29
  • Ascaridole is an anthelmintic and also has antimalarial activity[1].

Name ascaridole
Synonyms Ascaridiol
1-methyl-4-propan-2-yl-2,3-dioxabicyclo[2.2.2]oct-5-ene
Askaridol
1,4-Peroxy-p-menth-2-ene
Ascarisin
1,4-epidioxy-p-menth-2-ene
Ascaridol
cis-Ascaridole
1,4-Peroxido-p-menthene-2
ASCARIDOLE
Ascaridole0 nnDiscontiuned Unable to ship
Ascaricum
1-methyl-4-(1-methylethyl)-2,3-dioxabicyclo[2.2.2]oct-5-ene
Description Ascaridole is an anthelmintic and also has antimalarial activity[1].
Related Catalog
References

[1]. Pollack, et al. The effect of ascaridole on the in vitro development ofPlasmodium falciparum . Parasitol Res 76, 570–572 (1990).

Density 1.051 g/cm3
Boiling Point 172.3ºC at 760 mmHg
Melting Point 3.3ºC
Molecular Formula C10H16O2
Molecular Weight 168.23
Flash Point 55.9ºC
Exact Mass 168.11500
PSA 18.46000
LogP 2.45170
Index of Refraction 1.498

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OT0175000
CHEMICAL NAME :
p-Menth-2-ene, 1,4-epidioxy-
CAS REGISTRY NUMBER :
512-85-6
LAST UPDATED :
199710
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C10-H16-O2
MOLECULAR WEIGHT :
168.26
WISWESSER LINE NOTATION :
T66 A B AO BO DUTJ CY F

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon Rd., San Romon, CA 94583) Volume(issue)/page/year: -,1,1961 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 7,252,1948
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 7,252,1948
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
250 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 24,359,1925 ** TUMORIGENIC DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
25 gm/kg/42W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 35,707,1965
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
38 gm/kg/63W-I
TOXIC EFFECTS :
Tumorigenic - equivocal tumorigenic agent by RTECS criteria Skin and Appendages - tumors Tumorigenic - tumors at site of application
REFERENCE :
14JTAF "Mycotoxins in Foodstuffs, Proceedings of the Symposium held at the Massachusetts Institute of Technology, 1964," Wogan, G.N., ed., Cambridge, MA, MIT Press, 1965 Volume(issue)/page/year: -,275,1965
HS Code 2932999099

~97%

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Literature: Ribeiro, Sonia M.; Serra, Armenio C.; Rocha Gonsalves, A.M.d'A. Tetrahedron, 2007 , vol. 63, # 33 p. 7885 - 7891

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Literature: Jary, Walther G.; Ganglberger, Thorsten; Poechlauer, Peter; Falk, Heinz Monatshefte fur Chemie, 2005 , vol. 136, # 4 p. 537 - 541

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Literature: Nardello, Veronique; Herve, Melanie; Alsters, Paul L.; Aubry, Jean-Marie Advanced Synthesis and Catalysis, 2002 , vol. 344, # 2 p. 184 - 191

~36%

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Literature: Nitz, Siegfried; Kollmannsberger, Hubert; Spraul, Martin H.; Drawert, Friedrich Phytochemistry (Elsevier), 1989 , vol. 28, # 11 p. 3051 - 3054

~38%

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Literature: Nitz, Siegfried; Kollmannsberger, Hubert; Spraul, Martin H.; Drawert, Friedrich Phytochemistry (Elsevier), 1989 , vol. 28, # 11 p. 3051 - 3054

~90%

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Detail
Literature: Matusch, Rudolf; Schmidt, Gerhard Angewandte Chemie, 1988 , vol. 100, # 5 p. 729 - 730

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Literature: Schenck; Gollnick Journal de Chimie Physique et de Physico-Chimie Biologique, 1958 , vol. 55, p. 892

~%

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Literature: Schenck et al. Justus Liebigs Annalen der Chemie, 1953 , vol. 584, p. 125,149 Full Text Show Details Schering A. G. Patent: DE752437 , 1941 ; DRP/DRBP Org.Chem. Full Text Show Details Schenck; Ziegler Naturwissenschaften, 1944 , vol. 32, p. 157

~%

512-85-6 structure

512-85-6

Literature: Schenck et al. Justus Liebigs Annalen der Chemie, 1953 , vol. 584, p. 125,149 Full Text Show Details Schering A. G. Patent: DE752437 , 1941 ; DRP/DRBP Org.Chem. Full Text Show Details Schenck; Ziegler Naturwissenschaften, 1944 , vol. 32, p. 157
HS Code 2932999099
Summary 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%