351071-90-4

351071-90-4 structure

Name: TGX-155
Chemical Name: 8-(4-fluoro-2-methylphenoxy)-2-morpholin-4-yl-1H-quinolin-4-one
CAS Number: 351071-90-4
Molecular Formula: C₂₀H₁₉FN₂O₃
Molecular Weight: 354.37
Catalog: Signaling Pathways PI3K/Akt/mTOR PI3K
Create Date: 2017-03-10 00:41:05
Modify Date: 2024-02-04 08:33:24
TGX-155 (AZ12649385) is a selective inhibitor of PI3Kβ. TGX-155 has potential applications in antithrombotic therapy[1][2][3].

Name	8-(4-fluoro-2-methylphenoxy)-2-morpholin-4-yl-1H-quinolin-4-one
Synonyms	tgx-155

Description	TGX-155 (AZ12649385) is a selective inhibitor of PI3Kβ. TGX-155 has potential applications in antithrombotic therapy[1][2][3].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> PI3K/Akt/mTOR >> PI3K
Target	PI3Kβ
In Vivo	TGX-155 (1.5 mg/kg 和 2.5 mg/kg；静脉注射；单剂量) 以时间和剂量依赖性方式显著改善了兔颈动脉损伤中的循环血流量减少 (CFRs)[3]。
References	[1]. Verheijen J C, et al. Phosphatidylinositol 3-kinase (PI3K) inhibitors as anticancer drugs[J]. Drugs Future, 2007, 32(6): 537-547. [2]. Nylander S, et al. Human target validation of phosphoinositide 3-kinase (PI3K)β: effects on platelets and insulin sensitivity, using AZD6482 a novel PI3Kβ inhibitor. J Thromb Haemost. 2012 Oct;10(10):2127-36. [3]. Sturgeon SA, et al. Adaptation of the Folts and electrolytic methods of arterial thrombosis for the study of anti-thrombotic molecules in small animals. J Pharmacol Toxicol Methods. 2006 Jan-Feb;53(1):20-9.