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82801-73-8

82801-73-8 structure
82801-73-8 structure
  • Name: RKRARKE
  • Chemical Name: cGMP Dependent Kinase Inhibitor Peptide
  • CAS Number: 82801-73-8
  • Molecular Formula: C38H74N18O10
  • Molecular Weight: 943.11
  • Catalog: Research Areas Cancer
  • Create Date: 2018-12-31 17:37:55
  • Modify Date: 2024-01-02 09:36:44
  • PKG inhibitor peptide is an ATP-competitive inhibitor of cGMP-dependent protein kinase (PKG), with a Ki of 86 μM[1].

Name cGMP Dependent Kinase Inhibitor Peptide
Synonyms L-Glutamic acid, N-(diaminomethylene)-L-ornithyl-L-lysyl-N-(diaminomethylene)-L-ornithyl-L-alanyl-N-(diaminomethylene)-L-ornithyl-L-lysyl-
Alg-Lys-Arg-Ala-Arg-Lys-Glu
cGMP-Dependent Protein Kinase Inhibitor Peptide
ARG-LYS-ARG-ALA-ARG-LYS-GLU
arginyl-lysyl-arginyl-alanyl-arginyl-lysyl-glutamic acid
RKRARKE
PKG INHIBITOR
PROTEIN KINASE G INHIBITOR
N-(Diaminomethylene)-L-ornithyl-L-lysyl-N-(diaminomethylene)-L-ornithyl-L-alanyl-N-(diaminomethylene)-L-ornithyl-L-lysyl-L-glutamic acid
H-ARG-LYS-ARG-ALA-ARG-LYS-GLU-OH
Description PKG inhibitor peptide is an ATP-competitive inhibitor of cGMP-dependent protein kinase (PKG), with a Ki of 86 μM[1].
Related Catalog
Target

Ki: 86 μM (PKG)[1]

In Vitro Summary of experiments showing that intracellular dialysis of postsynaptic cells with PKG inhibitor PKG inhibitor peptide (1 mM) failed to alter the induction of long-term depression (CCh-LTD)[2].
References

[1]. Bhatnagar D, et al. Synthetic peptide analogues differentially alter the binding affinities of cyclic nucleotide dependent protein kinases for nucleotide substrates. Biochemistry. 1988 Mar 22;27(6):1988-94.

[2]. Chiung-Chun Huang, et al. Activation of muscarinic acetylcholine receptors induces a nitric oxide-dependent long-term depression in rat medial prefrontal cortex. Cereb Cortex. 2010 Apr;20(4):982-96.

Density 1.5±0.1 g/cm3
Molecular Formula C38H74N18O10
Molecular Weight 943.11
Exact Mass 942.583557
PSA 512.96000
LogP -5.78
Index of Refraction 1.658