200432-86-6

200432-86-6 structure

Name: UB 165 fumarate
Chemical Name: UB 165 fumarate,2-(6-Chloro-3-pyridinyl)-9-azabicyclo[4.2.1]non-2-enefumarate
CAS Number: 200432-86-6
Molecular Formula: C₁₇H₁₉ClN₂O₄
Molecular Weight: 350.79700
Catalog: Signaling Pathways Membrane Transporter/Ion Channel nAChR
Create Date: 2019-01-02 15:21:10
Modify Date: 2024-01-09 09:54:28
UB-165 is a nAChR agonist, being a full agonist of the α3β2 isoform and a partial agonist of the α4β2* isoform, with a Ki value of 0.27 nM for [3H]-nicotine binding in rat brain[1].

Name	UB 165 fumarate,2-(6-Chloro-3-pyridinyl)-9-azabicyclo[4.2.1]non-2-enefumarate
Synonyms	Compound 401 UB 165 FUMARATE

Description	UB-165 is a nAChR agonist, being a full agonist of the α3β2 isoform and a partial agonist of the α4β2* isoform, with a Ki value of 0.27 nM for [3H]-nicotine binding in rat brain[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Neurological Disease
In Vitro	UB-165 刺激 [3H]-多巴胺从纹状体突触释放，EC50 值为 88 nM[1]。
References	[1]. Sharples CG, et al. UB-165: a novel nicotinic agonist with subtype selectivity implicates the alpha4beta2* subtype in the modulation of dopamine release from rat striatal synaptosomes. J Neurosci. 2000 Apr 15;20(8):2783-91.