91917-65-6
91917-65-6 structure
- Name: Ro 15-4513
- Chemical Name: ethyl 8-azido-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
- CAS Number: 91917-65-6
- Molecular Formula: C15H14N6O3
- Molecular Weight: 326.31000
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
- Create Date: 2017-09-11 18:03:11
- Modify Date: 2025-08-27 12:12:59
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Ro15-4513, imidazobenzodiazepinone derivative, is a partial inverse agonist of benzodiazepine receptor (BZR)[1]. Ro15-4513 is a potent ethanol antagonist[2]. Ro15-4513 has anti-anxiety effect[3].
| Name | ethyl 8-azido-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate |
|---|---|
| Synonyms |
Ethyl-8-azido-5,6-dihydro-5-methyl-6-oxo-4H-imidazo-1,4-benzodiazepine-3-carboxylate
Tocriscreen Total |
| Description | Ro15-4513, imidazobenzodiazepinone derivative, is a partial inverse agonist of benzodiazepine receptor (BZR)[1]. Ro15-4513 is a potent ethanol antagonist[2]. Ro15-4513 has anti-anxiety effect[3]. |
|---|---|
| Related Catalog | |
| Target |
BZR[1]; ethanol[2]; |
| In Vitro | Ro15-4513 usually acts as a partial inverse agonist at GABAA receptors, except an agonist for α4 and α6 subunit-containing ones[3]. |
| In Vivo | Ro 15-4513 (i.p.; 3 mg/kg; 10 min before being tested) completely inhibits the ethanol-induced (1.8 g/kg) reduction in total locomotor activity and partly the reduction in rearing[2]. Ro 15-4513 (i.p.; 3 mg/kg; 15 min before administration of 1.5 g/kg ethanol) reverses ethanol-induced sedation in GABAA receptor δ subunit-deficient mice[2]. Animal Model: Male C57BL/6J mice[2] Dosage: 3 mg/kg Administration: I.p.; 10 min before being tested Result: Completely inhibited the ethanol-induced reduction in total locomotor activity and partly the reduction in rearing. |
| References |
| Molecular Formula | C15H14N6O3 |
|---|---|
| Molecular Weight | 326.31000 |
| Exact Mass | 326.11300 |
| PSA | 114.18000 |
| LogP | 1.96706 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |