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472981-92-3

472981-92-3 structure
472981-92-3 structure
  • Name: SB-366791
  • Chemical Name: (E)-3-(4-chlorophenyl)-N-(3-methoxyphenyl)prop-2-enamide
  • CAS Number: 472981-92-3
  • Molecular Formula: C16H14ClNO2
  • Molecular Weight: 287.741
  • Catalog: Signaling Pathways Membrane Transporter/Ion Channel TRP Channel
  • Create Date: 2017-10-26 03:07:19
  • Modify Date: 2025-08-23 18:54:21
  • SB-366791 is a potent , competitive and selective vanilloid receptor (VR1/TRPV1) antagonist with IC50 of 5.7±1.2 nMtarget: VR1/TRPV1IC 50: 5.7±1.2 nM [1] SB-366791 produced a concentration-dependent inhibition of the response to capsaicin with an apparent pKb of 7.74±0.08. Schild analysis indicated a competitive mechanism of action with a pA2 of 7.71.[1] SB-366791 showed a concentration-dependent potentiation of pH 5-induced 45Ca2+uptake in CHO cells expressing rat TRPV1 but not in untransfected cells[2]
Name (E)-3-(4-chlorophenyl)-N-(3-methoxyphenyl)prop-2-enamide
Synonyms 2-Propenamide, 3-(4-chlorophenyl)-N-(3-methoxyphenyl)-, (2E)-
N-(3-Methoxyphenyl)-4-chlorocinnamide
(2E)-3-(4-Chlorophenyl)-N-(3-methoxyphenyl)acrylamide
SB-366791
Description SB-366791 is a potent , competitive and selective vanilloid receptor (VR1/TRPV1) antagonist with IC50 of 5.7±1.2 nMtarget: VR1/TRPV1IC 50: 5.7±1.2 nM [1] SB-366791 produced a concentration-dependent inhibition of the response to capsaicin with an apparent pKb of 7.74±0.08. Schild analysis indicated a competitive mechanism of action with a pA2 of 7.71.[1] SB-366791 showed a concentration-dependent potentiation of pH 5-induced 45Ca2+uptake in CHO cells expressing rat TRPV1 but not in untransfected cells[2]
Related Catalog
References

[1]. M.J. Gunthorpe et al. Identification and characterisation of SB-366791, a potent and selective vanilloid receptor (VR1/TRPV1) antagonist. Neuropharmacology, 2004 Jan, 46(1):133-49.

[2]. Gavva NR et al. Proton Activation Does Not Alter Antagonist Interaction with the Capsaicin-Binding Pocket of TRPV1. Mol Pharmacol, 2005 Dec, 68(6), 1524-33.
Density 1.3±0.1 g/cm3
Boiling Point 494.2±45.0 °C at 760 mmHg
Melting Point 169 °C
Molecular Formula C16H14ClNO2
Molecular Weight 287.741
Flash Point 252.7±28.7 °C
Exact Mass 287.071320
PSA 38.33000
LogP 4.52
Vapour Pressure 0.0±1.3 mmHg at 25°C
Index of Refraction 1.650
Storage condition -20℃
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
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title: CAS No. 472981-92-3 | Chemsrc address: https://m.chemsrc.com/en/baike/587432.html

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