205242-62-2
205242-62-2 structure
- Name: NAS-181
- Chemical Name: methanesulfonic acid,(2R)-2-[[3-(morpholin-4-ylmethyl)-2H-chromen-8-yl]oxymethyl]morpholine
- CAS Number: 205242-62-2
- Molecular Formula: C21H34N2O10S2
- Molecular Weight: 538.63200
- Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
- Create Date: 2016-09-30 02:01:31
- Modify Date: 2024-01-02 11:20:30
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NAS-181 is a potent and selective rat 5-hydroxytryptamine1B (r5-HT1B) antagonist with an Ki value of 47 nM. NAS-181 increases the 5-HTP accumulation in rat brain regions[1].
| Name | methanesulfonic acid,(2R)-2-[[3-(morpholin-4-ylmethyl)-2H-chromen-8-yl]oxymethyl]morpholine |
|---|---|
| Synonyms | nas-181 |
| Description | NAS-181 is a potent and selective rat 5-hydroxytryptamine1B (r5-HT1B) antagonist with an Ki value of 47 nM. NAS-181 increases the 5-HTP accumulation in rat brain regions[1]. |
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| Related Catalog | |
| In Vitro | NAS-181 (compound (R)-25) (0-1000 nM) increases the K+-stimulated release of [3H]-5-HT from rat occipital cortical slices[1]. NAS-181 (3 mg/kg; s.c.) increases in the number of wet dog shakes in rats, and the effect is abolished by pretreatment of the rats with the tryptophan hydroxylase inhibitor p-chlorophenylalanine (pCPA) (200 mg/kg; i.p.)[1]. |
| In Vivo | NAS-181 (20 mg/kg; s.c.) increases the 5-HTP accumulation in rat brain regions[1]. Animal Model: Rats[1] Dosage: 20 mg/kg Administration: S.c. Result: Significantly increased the 5-HTP accumulation in hypothalamus, hippocampus, frontal cortex, striatum, and the ratio 5-HIAA/5-HT in these brain regions was even more elevated (40−60%). |
| References |
| Boiling Point | 765ºC at 760 mmHg |
|---|---|
| Molecular Formula | C21H34N2O10S2 |
| Molecular Weight | 538.63200 |
| Flash Point | 416.5ºC |
| Exact Mass | 538.16500 |
| PSA | 177.69000 |
| LogP | 2.59810 |
| Vapour Pressure | 1.31E-24mmHg at 25°C |