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Product Name: (2R)-2-[[[3-(4-MORPHOLINYLMETHYL)-2H-1-BENZOPYRAN-8-YL]OXY]METHYL]MORPHOLINE DIMETHANESULFONATE
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205242-62-2

205242-62-2 structure

Name: NAS-181
Chemical Name: methanesulfonic acid,(2R)-2-[[3-(morpholin-4-ylmethyl)-2H-chromen-8-yl]oxymethyl]morpholine
CAS Number: 205242-62-2
Molecular Formula: C₂₁H₃₄N₂O₁₀S₂
Molecular Weight: 538.63200
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2016-09-30 02:01:31
Modify Date: 2025-08-26 10:05:39
NAS-181 is a potent and selective rat 5-hydroxytryptamine1B (r5-HT1B) antagonist with an Ki value of 47 nM. NAS-181 increases the 5-HTP accumulation in rat brain regions[1].

Name	methanesulfonic acid,(2R)-2-[[3-(morpholin-4-ylmethyl)-2H-chromen-8-yl]oxymethyl]morpholine
Synonyms	nas-181

Description	NAS-181 is a potent and selective rat 5-hydroxytryptamine1B (r5-HT1B) antagonist with an Ki value of 47 nM. NAS-181 increases the 5-HTP accumulation in rat brain regions[1].
Related Catalog	Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
In Vitro	NAS-181 (compound (R)-25) (0-1000 nM) increases the K+-stimulated release of [3H]-5-HT from rat occipital cortical slices[1]. NAS-181 (3 mg/kg; s.c.) increases in the number of wet dog shakes in rats, and the effect is abolished by pretreatment of the rats with the tryptophan hydroxylase inhibitor p-chlorophenylalanine (pCPA) (200 mg/kg; i.p.)[1].
In Vivo	NAS-181 (20 mg/kg; s.c.) increases the 5-HTP accumulation in rat brain regions[1]. Animal Model: Rats[1] Dosage: 20 mg/kg Administration: S.c. Result: Significantly increased the 5-HTP accumulation in hypothalamus, hippocampus, frontal cortex, striatum, and the ratio 5-HIAA/5-HT in these brain regions was even more elevated (40−60%).
References	[1]. Berg S, et al. (R)-(+)-2-[[[3-(Morpholinomethyl)-2H-chromen-8-yl]oxy]methyl] morpholine methanesulfonate: a new selective rat 5-hydroxytryptamine1B receptor antagonist. J Med Chem. 1998 May 21;41(11):1934-42.