Top Suppliers:I want be here
Related CAS#:
100929-99-5 90836-22-9
121722-58-5 76524-86-2
76122-99-1 138914-35-9
128245-88-5 281659-95-8
121185-76-0 62354-56-7
1158522-08-7 940364-43-2
134104-43-1 1420824-93-6
131615-57-1 1788543-57-6
6906-52-1 930439-75-1
1018584-77-4 1375289-11-4

100929-99-5

100929-99-5 structure
100929-99-5 structure
  • Name: H-Phe-Arg-βNA · 2 HCl
  • Chemical Name: 2-[(2-amino-3-phenylpropanoyl)amino]-5-(diaminomethylideneamino)-N-naphthalen-2-ylpentanamide,hydrochloride
  • CAS Number: 100929-99-5
  • Molecular Formula: C25H32Cl2N6O2
  • Molecular Weight: 519.46700
  • Catalog: Signaling Pathways Anti-infection Bacterial
  • Create Date: 2018-09-06 12:51:21
  • Modify Date: 2024-01-02 14:04:59
  • PAβN dihydrochloride (MC-207110 dihydrochloride) is an efflux pump inhibitor.
Name 2-[(2-amino-3-phenylpropanoyl)amino]-5-(diaminomethylideneamino)-N-naphthalen-2-ylpentanamide,hydrochloride
Synonyms 2-(2-amino-3-phenylpropanamido)-5-carbamimidamido-N-(naphthalen-2-yl)pentanamide hydrochloride
Phe-Arg-β-naphthylamide
PAβN (dihydrochloride)
Description PAβN dihydrochloride (MC-207110 dihydrochloride) is an efflux pump inhibitor.
Related Catalog
In Vitro PAβN increases the susceptibilities of the three pump-overexpressing mutants of P. aeruginosa to levofloxacin 64-fold. PAβN also potentiates the activity of levofloxacin against strain PAM2391 containing plasmid pAGH97 with the mexXY genes and against wild-type strain PAM1020. PAβN has an effect on susceptibilities to other antibiotics that are substrates of efflux pumps. PAβN increases levels of accumulation of efflux pump substrates inside the cell. It enhances the activity of levofloxacin against clinical isolates of P. aeruginosa[1]. PAβN reduces the MICs in nine ciprofloxacin-resistant isolates, and in four of these, PAβN increases the susceptibility by twofold. Moreover, PAβN restores ciprofloxacin susceptibility in five of the ciprofloxacin-resistant isolates. In addition, clear effects of NMP on the ciprofloxacin MICs are seen for 20 of these ciprofloxacin-resistant isolates[2]. PAβN permeabilizes bacterial membranes in a concentration-dependent manner at levels below those typically used in combination studies, and this additional mode of action should be considered when using PAβN as a control for efflux studies[3].
References

[1]. Lomovskaya O, et al. Identification and characterization of inhibitors of multidrug resistance efflux pumps in Pseudomonas aeruginosa: novel agents for combination therapy. Antimicrob Agents Chemother. 2001 Jan;45(1):105-16.

[2]. Kurinčič M, et al. Effects of efflux pump inhibitors on erythromycin, ciprofloxacin, and tetracycline resistance in Campylobacter spp. isolates. Microb Drug Resist. 2012 Oct;18(5):492-501.

[3]. Lamers RP, et al. The efflux inhibitor phenylalanine-arginine beta-naphthylamide (PAβN) permeabilizes the outer membrane of gram-negative bacteria. PLoS One. 2013;8(3):e60666.

Molecular Formula C25H32Cl2N6O2
Molecular Weight 519.46700
Exact Mass 518.19600
PSA 146.12000
LogP 6.05550
Storage condition 2-8℃
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
WGK Germany 3

Chemsrc provides CAS#:100929-99-5 MSDS, density, melting point, boiling point, structure, formula, molecular weight, synthetic route, etc.
title: CAS No. 100929-99-5 | Chemsrc address: https://m.chemsrc.com/en/baike/588953.html

Home | MSDS/SDS Database Search | Journals | Product Classification | Biologically Active Compounds | Selling Leads | About Us | Disclaimer

Copyright © 2024 ChemSrc All Rights Reserved