DC Chemicals Limited
China
Product Name: Methoctramine tetrahydrochloride
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

104807-46-7

104807-46-7 structure

Name: Methoctramine tetrahydrochloride
Chemical Name: Methoctramine hydrate
CAS Number: 104807-46-7
Molecular Formula: C₃₆H₆₆Cl₄N₄O₂
Molecular Weight: 728.74700
Catalog: Signaling Pathways GPCR/G Protein mAChR
Create Date: 2016-09-08 12:21:38
Modify Date: 2024-01-15 13:40:03
Methoctramine tetrahydrochloride is a potent and cardioselectivity antagonist of M2 muscarinic receptor. Methoctramine tetrahydrochloride can inhibit Muscarine-induced bradycardia in vivo[1][2][3].

Name	Methoctramine hydrate
Synonyms	N,N'-bis[6-[(2-methoxyphenyl)methylamino]hexyl]octane-1,8-diamine,tetrahydrochloride

Description	Methoctramine tetrahydrochloride is a potent and cardioselectivity antagonist of M2 muscarinic receptor. Methoctramine tetrahydrochloride can inhibit Muscarine-induced bradycardia in vivo[1][2][3].
Related Catalog	Signaling Pathways >> Neuronal Signaling >> mAChR Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> mAChR
Target	M2 muscarinic receptor[1]
In Vitro	Methoctramine tetrahydrochloride attenuates Acetylcholine (ACh)- and Arecaidine propargyl ester (APE)-induced increases in PG synthesis in a concentration-dependent manner[1]. Methoctramine (0.01-1 μM) tetrahydrochloride causes facilitation of contractions induced by both pre- and postganglionic nerve stimulation in the guinea-pig isolated, innervated tracheal tube preparation[2]. Methoctramine (≥10 μM) tetrahydrochloride reduces responses to both nerve stimulation and exogenous ACh[2].
In Vivo	Methoctramine (300 µg/kg; i.v.) tetrahydrochloride strongly inhibits the Methacholine- and Muscarine-induced bradycardia in the anaesthetized rat, respectively[3].
References	[1]. Jaiswal N, et, al. Methoctramine, a cardioselective antagonist: muscarinic receptor mediating prostaglandin synthesis in isolated rabbit heart. Eur J Pharmacol. 1991 Jan 3;192(1):63-70. [2]. Watson N, et, al. Actions of methoctramine, a muscarinic M2 receptor antagonist, on muscarinic and nicotinic cholinoceptors in guinea-pig airways in vivo and in vitro. Br J Pharmacol. 1992 Jan;105(1):107-12. [3]. Wess J, et, al. Methoctramine selectively blocks cardiac muscarinic M2 receptors in vivo. Naunyn Schmiedebergs Arch Pharmacol. 1988 Sep;338(3):246-9.

Boiling Point	681.9ºC at 760mmHg
Molecular Formula	C₃₆H₆₆Cl₄N₄O₂
Molecular Weight	728.74700
Flash Point	316.7ºC
Exact Mass	726.39400
PSA	66.58000
LogP	11.99540
Vapour Pressure	1.89E-18mmHg at 25°C
Storage condition	2-8°C

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