80714-61-0

80714-61-0 structure

Name: Semax
Chemical Name: L-Methionyl-L-α-glutamylhistidyl-L-phenylalanyl-L-prolylglycyl-L- proline
CAS Number: 80714-61-0
Molecular Formula: C₃₇H₅₁N₉O₁₀S
Molecular Weight: 813.92000
Catalog: Research Areas Neurological Disease
Create Date: 2016-10-23 02:10:11
Modify Date: 2024-01-02 18:34:52
MEHFPGP is a nootropic neuroprotective peptide. MEHFPGP can be used in the research of brain stroke[1][2].

Name	L-Methionyl-L-α-glutamylhistidyl-L-phenylalanyl-L-prolylglycyl-L- proline
Synonyms	1,3,5-tris[6-isocyanatohexyl]-2,4,6-trioxo-s-triazine HMDI trimer tris(6-isocyanatohexyl) isocyanurate L-2-methylleucine methyl ester 1,3,5-Tris(isocyanatohexamethylene)isocyanurate Lys(Z)-OBzl.TosOH H-MeLeu-OMe hexamethylene diisocyanate isocyanurate trimeric hexamethylene diisocyanate H-Lys(Z)-OBzlTosOH H-Met-Glu-His-Phe-Pro-Gly-Pro TsOHH-Lys(Z)-OBzl Desmodur N 3390 BA Met-Glu-His-Phe-Pro-Gly-Pro

Description	MEHFPGP is a nootropic neuroprotective peptide. MEHFPGP can be used in the research of brain stroke[1][2].
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
In Vitro	MEHFPGP (25 μM and 100 μM, 48 h) reduces the Abeta oligomers (100 μM) levels[2]. MEHFPGP (100 nM) increase survival of cholinergic basal forebrain neurons[3]. MEHFPGP (100 nM) stimulates activity of choline acetyltransferase in dissociated basal forebrain tissue culture[3]. MEHFPGP (10 μM, 24 h) stimulates the synthesis of brain-derived neurotrophic factor (BDNF) in astrocytes cultured from rat basal forebrain[4].
In Vivo	MEHFPGP (Semax, 100 μg/kg, i.p.) promotes the formation and functioning of the vascular system in Ischemia (pMCAO) rats[1]. MEHFPGP (50 µg and 250 µg, 100 µL/kg, intranasal inhalation) increases levels of b BDNF protein in rat basal forebrain[5]. Animal Model: Ischemia (pMCAO) rats[1]. Dosage: 100 μg/kg Administration: Intraperitoneal injections (i.p.), performed 15 min, 1, 4 and 8 h after permanent middle cerebral artery occlusion (pMCAO). Result: Increased the immune response (upregulation of transcripts). Animal Model: Rats[5] Dosage: 50 µg, 250 µg, 100 µL/kg Administration: Intranasal inhalation Result: Increased levels of brain-derived neurotrophic factor (BDNF) protein in rat basal forebrain.