174709-30-9

174709-30-9 structure

Name: BPIQ-I
Chemical Name: N-(3-bromophenyl)-3-methylimidazo[4,5-g]quinazolin-8-amine
CAS Number: 174709-30-9
Molecular Formula: C₁₆H₁₂BrN₅
Molecular Weight: 354.20400
Catalog: Signaling Pathways JAK/STAT Signaling EGFR
Create Date: 2017-06-10 22:58:02
Modify Date: 2024-01-21 13:10:25
BPIQ-I (PD 159121) is a potent and ATP-competitive EGFR tyrosine kinase inhibitor.. BPIQ-I shows anti-proliferative actively[1][2].

Name	N-(3-bromophenyl)-3-methylimidazo[4,5-g]quinazolin-8-amine
Synonyms	HMS3229C05 8-[(3-Bromophenyl)amino]-3-methyl-3H-imidazo[4,5-g]-quinazoline Imidazoquinazoline deriv. 12 IN1402 bpiq-i

Description	BPIQ-I (PD 159121) is a potent and ATP-competitive EGFR tyrosine kinase inhibitor.. BPIQ-I shows anti-proliferative actively[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> JAK/STAT Signaling >> EGFR Signaling Pathways >> Protein Tyrosine Kinase/RTK >> EGFR
In Vitro	BPIQ-I (0-50 µM; 3 days) 具有抗增殖活性，对 A-431, MDA-MB-468, U-87, SKOV-3, MDAMB-231 细胞的 EC50 值分别为 >50、30、>50、6.5、>50 µM [1]. BPIQ-I (10 nM) 通过与 ATP 竞争来阻断 erbB RTK，从而消除 CO2 敏感性[2]。 Cell Viability Assay [1] Cell Line: A-431, MDA-MB-468, U-87, SKOV-3, MDAMB-231 cells Concentration: 0-50 µM Incubation Time: 3 days Result: Inhibited cells growth with EC50s of >50, 30, >50, 6.5, >50 µM for A-431, MDA-MB-468, U-87, SKOV-3, MDAMB-231 cells, respectively.
References	[1]. Rae JM, et al. Evaluation of novel epidermal growth factor receptor tyrosine kinase inhibitors. Breast Cancer Res Treat. 2004 Jan;83(2):99-107. [2]. Zhou Y, et al. Role of a tyrosine kinase in the CO2-induced stimulation of HCO3- reabsorption by rabbit S2 proximal tubules. Am J Physiol Renal Physiol. 2006 Aug;291(2):F358-67.