1306761-53-4

1306761-53-4 structure

Name: RP-001
Chemical Name: N-{4-[5-(3-Cyano-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl]-2,3-di hydro-1H-inden-1-yl}-β-alanine hydrochloride (1:1)
CAS Number: 1306761-53-4
Molecular Formula: C₂₄H₂₄N₄O₄
Molecular Weight: 468.93300
Catalog: Signaling Pathways GPCR/G Protein LPL Receptor
Create Date: 2016-04-04 17:34:19
Modify Date: 2024-02-06 18:15:22
RP-001 is a picomolar short-acting S1P1 (EDG1) selective agonist, with an EC50 of 9 pM. RP-00 induces internalization and polyubiquitination of S1P1. RP-001 has little activity on S1P2-S1P4 and only moderate affinity for S1P5[1].

Name	N-{4-[5-(3-Cyano-4-isopropoxyphenyl)-1,2,4-oxadiazol-3-yl]-2,3-di hydro-1H-inden-1-yl}-β-alanine hydrochloride (1:1)

Description	RP-001 is a picomolar short-acting S1P1 (EDG1) selective agonist, with an EC50 of 9 pM. RP-00 induces internalization and polyubiquitination of S1P1. RP-001 has little activity on S1P2-S1P4 and only moderate affinity for S1P5[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> LPL Receptor Research Areas >> Neurological Disease
In Vitro	RP-001 elicits dose-dependent lymphopenia of CD4+ T cells. RP-001 induces acute lymphopenia with rapid recovery to untreated levels[1].
In Vivo	RP-001 causes dose-dependent rapid lymphopenia with an EC50 of 0.03 mg/kg[1].
References	[1]. Cahalan SM, et al. Actions of a picomolar short-acting S1P₁ agonist in S1P₁-eGFP knock-in mice. Nat Chem Biol. 2011 May;7(5):254-6.