173352-21-1

173352-21-1 structure

Name: Fabomotizole
Chemical Name: 4-[2-[(6-ethoxy-1H-benzimidazol-2-yl)sulfanyl]ethyl]morpholine
CAS Number: 173352-21-1
Molecular Formula: C₁₅H₂₁N₃O₂S
Molecular Weight: 307.411
Catalog: Research Areas Neurological Disease
Create Date: 2018-06-12 22:11:13
Modify Date: 2024-01-02 09:37:46
Fabomotizole (CM346) is an anxiolytic drug; produces anxiolytic and neuroprotective effects without any sedative or muscle relaxant actions.IC50 value:Target: anxiolytic agent Afobazole's mechanism of action remains poorly defined however, with GABAergic, NGF and BDNF release promoting, MT1 receptor antagonism, MT3 receptor antagonism, and sigma agonism suggested as potential mechanisms. Afobazole was shown to inhibit MAO-A reversibly and there might be also some involvement with serotonin receptors. Afobazole has found little clinical use outside of Russia and has not been evaluated by the FDA.

Name	4-[2-[(6-ethoxy-1H-benzimidazol-2-yl)sulfanyl]ethyl]morpholine
Synonyms	Afobazole UNII-0F8K1X115C 1H-Benzimidazole, 6-ethoxy-2-[[2-(4-morpholinyl)ethyl]thio]- Fabomotizole Obenoxazine 6-Ethoxy-2-{[2-(4-morpholinyl)ethyl]sulfanyl}-1H-benzimidazole CM 346

Description	Fabomotizole (CM346) is an anxiolytic drug; produces anxiolytic and neuroprotective effects without any sedative or muscle relaxant actions.IC50 value:Target: anxiolytic agent Afobazole's mechanism of action remains poorly defined however, with GABAergic, NGF and BDNF release promoting, MT1 receptor antagonism, MT3 receptor antagonism, and sigma agonism suggested as potential mechanisms. Afobazole was shown to inhibit MAO-A reversibly and there might be also some involvement with serotonin receptors. Afobazole has found little clinical use outside of Russia and has not been evaluated by the FDA.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
References	[1]. Afobazole, From Wikipedia

3647-69-6

55489-15-1

173352-21-1

Literature: Nauchno-Issledovatelsky Institut Farmakologii Rossiiskoi Akademii Meditsinskikh Nauk Patent: US6376666 B1, 2002 ;