DC Chemicals Limited
China
Product Name: HMN-154
Price: $500.0/100mg $900.0/250mg $1700.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: (E)-4-[2-{2-[N-(4-Methoxybenzenesulfonyl)amino]phenyl}ethenyl ]pyridine
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

173528-92-2

173528-92-2 structure

173528-92-2 structure

Name: HMN-154
Chemical Name: 4-methoxy-N-[2-(2-pyridin-4-ylethenyl)phenyl]benzenesulfonamide
CAS Number: 173528-92-2
Molecular Formula: C₂₀H₁₈N₂O₃S
Molecular Weight: 366.43400
Catalog: Research Areas Cancer
Create Date: 2018-12-24 13:51:11
Modify Date: 2024-01-10 21:43:40
HMN-154 is a novel benzenesulfonamide anticancer compound; inhibits KB and colon38 cells with IC50 values of 0.0026 and 0.003 μg/mL, respectively.

Name	4-methoxy-N-[2-(2-pyridin-4-ylethenyl)phenyl]benzenesulfonamide
Synonyms	HMN-154

Description	HMN-154 is a novel benzenesulfonamide anticancer compound; inhibits KB and colon38 cells with IC50 values of 0.0026 and 0.003 μg/mL, respectively.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Cancer
Target	IC50: 0.0026 μg/mL (KB cells), 0.003 μg/mL (colon38 cells)[1]
In Vitro	HMN-154 interacts with NF-YB and thereby interrupts the binding of the NF-Y heterotrimer to DNA. NF-YB and thymosin β-10 are specific cellular binding proteins of HMN-154 and that this shared region is necessary for the binding to HMN-154. HMN-154 inhibits DNA binding of NF-Y to the human major histocompatibility complex class II human leukocyte antigen DRA Y-box sequence in a dose-dependent manner. HMN-154 shows very strong cytotoxicity against KB and colon38 cells with an IC50 value of 0.0026 and 0.003 μg/mL, respectively. HMN-154/BSA binds recombinant NF-YB or thymosin β-10 and the binding is inhibited by the addition of HMN-154 as the competitor. The binding between HMN-154 and NF-YB is specific and depends on its cytotoxicity[1].
Cell Assay	Cells are seeded into a 96-well microplate at a cell density of 10000/well. Drug is added on the next day, and the plate then is incubated for 72 h at 37°C. The growth inhibitory concentration is measured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay[1].
References	[1]. Tanaka H, et al. Isolation of cDNAs encoding cellular drug-binding proteins using a novel expression cloning procedure: drug-western. Mol Pharmacol. 1999 Feb;55(2):356-63.

Density	1.313g/cm3
Boiling Point	553.7ºC at 760 mmHg
Molecular Formula	C₂₀H₁₈N₂O₃S
Molecular Weight	366.43400
Flash Point	288.6ºC
Exact Mass	366.10400
PSA	76.67000
LogP	5.21520
Vapour Pressure	2.67E-12mmHg at 25°C
Index of Refraction	1.651
Storage condition	2-8℃

138386-71-7 structure

138386-71-7

98-68-0 structure

98-68-0

~%

173528-92-2 structure

173528-92-2

Literature: Nippon Shinyaku Company, Limited Patent: US5972976 A1, 1999 ;