Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1-(2-chloroethyl)-3-[2-[2-[(2-chloroethyl-nitroso-carbamoyl)amino]ethy ldisulfanyl]ethyl]-1-nitroso-urea
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Purity: 98.0%
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77469-44-4

77469-44-4 structure

Name: 1-(2-chloroethyl)-3-[2-[2-[(2-chloroethyl-nitroso-carbamoyl)amino]ethy ldisulfanyl]ethyl]-1-nitroso-urea
Chemical Name: 1-(2-chloroethyl)-3-[2-[2-[[2-chloroethyl(nitroso)carbamoyl]amino]ethyldisulfanyl]ethyl]-1-nitrosourea
CAS Number: 77469-44-4
Molecular Formula: C₁₀H₁₈Cl₂N₆O₄S₂
Molecular Weight: 421.32400
Create Date: 2017-05-19 19:20:48
Modify Date: 2024-01-02 13:45:28

Name	1-(2-chloroethyl)-3-[2-[2-[[2-chloroethyl(nitroso)carbamoyl]amino]ethyldisulfanyl]ethyl]-1-nitrosourea
Synonyms	Ditiomustine CNCC I.C.I.G. 1325

Molecular Formula	C₁₀H₁₈Cl₂N₆O₄S₂
Molecular Weight	421.32400
Exact Mass	420.02100
PSA	201.14000
LogP	2.57780

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YT2150000

CHEMICAL NAME :: Urea, 1,1'-dithiodiethylenebis(3-(2-chloroethyl)-3-nitroso-

CAS REGISTRY NUMBER :: 77469-44-4

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C10-H18-Cl2-N6-O4-S2

MOLECULAR WEIGHT :: 421.36

WISWESSER LINE NOTATION :: ONNG2&VM2SS2MVNNO&2G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 280 mg/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

MUTATION DATA

TYPE OF TEST :: Mutation test systems - not otherwise specified

TEST SYSTEM :: Rodent - mouse Cells - not otherwise specified

DOSE/DURATION :: 20 mg/L

REFERENCE :: INSSDM INSERM Symposium. (Elsevier Science Pub. Co., Inc., 52 Vanderbilt Ave., New York, NY 10017) No.1- 1975- Volume(issue)/page/year: 19,229,1981

80354-51-4

56-17-7

~73%

77469-44-4

Literature: Martinez, Jean; Oiry, Joel; Imbach, Jean Louis; Winternitz, Francois Journal of Medicinal Chemistry, 1982 , vol. 25, # 2 p. 178 - 182

56-17-7

80354-53-6

~75%

77469-44-4

Literature: Martinez, Jean; Oiry, Joel; Imbach, Jean Louis; Winternitz, Francois Journal of Medicinal Chemistry, 1982 , vol. 25, # 2 p. 178 - 182

56-17-7

80354-49-0

~75%

77469-44-4

Literature: Martinez, Jean; Oiry, Joel; Imbach, Jean Louis; Winternitz, Francois Journal of Medicinal Chemistry, 1982 , vol. 25, # 2 p. 178 - 182

56-17-7

80354-55-8

~76%

77469-44-4

Literature: Martinez, Jean; Oiry, Joel; Imbach, Jean Louis; Winternitz, Francois Journal of Medicinal Chemistry, 1982 , vol. 25, # 2 p. 178 - 182

90213-05-1

77469-44-4

Literature: Oiry; Pompon; Madelmont; Imbach European Journal of Medicinal Chemistry, 1984 , vol. 19, # 4 p. 311 - 314

77456-13-4

77469-44-4

77456-14-5

90213-04-0

Literature: Oiry; Imbach European Journal of Medicinal Chemistry, 1984 , vol. 19, # 4 p. 305 - 309

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