74847-35-1
74847-35-1 structure
- Name: Pyronaridine
- Chemical Name: 4-[(7-chloro-2-methoxy-1,5-dihydrobenzo[b][1,5]naphthyridin-10-yl)imino]-2,6-bis(pyrrolidin-1-ylmethyl)cyclohexa-2,5-dien-1-one
- CAS Number: 74847-35-1
- Molecular Formula: C29H32ClN5O2
- Molecular Weight: 518.050
- Catalog: Research Areas Infection
- Create Date: 2018-02-16 08:00:00
- Modify Date: 2024-01-04 14:40:19
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Pyronaridine is an orally active Mannich base anti-malarial agent. Pyronaridine is active against P. falciparum and Echinococcus granulosus infection[1][2].
| Name | 4-[(7-chloro-2-methoxy-1,5-dihydrobenzo[b][1,5]naphthyridin-10-yl)imino]-2,6-bis(pyrrolidin-1-ylmethyl)cyclohexa-2,5-dien-1-one |
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| Synonyms |
4-[(7-Chloro-2-methoxybenzo[b]-1,5-naphthyridin-10-yl)amino]-2,6-bis(1-pyrrolidinylmethyl)phenol
C29H32ClN5O2 4-[(7-Chloro-2-methoxybenzo[b][1,5]naphthyridin-10-yl)amino]-2,6-bis(1-pyrrolidinylmethyl)phenol Benzonaphthyridine 7351 Malaridine pyronaridine phosphate salt Phenol, 4-[(7-chloro-2-methoxybenzo[b][1,5]naphthyridin-10-yl)amino]-2,6-bis(1-pyrrolidinylmethyl)- Pyronaridine UNII-TD3P7Q3SG6 4-[(7-chloro-2-methoxybenzo[b][1,5]naphthyridin-10-yl)amino]-2,6-bis(pyrrolidin-1-ylmethyl)phenol |
| Description | Pyronaridine is an orally active Mannich base anti-malarial agent. Pyronaridine is active against P. falciparum and Echinococcus granulosus infection[1][2]. |
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| Related Catalog | |
| In Vitro | Pyronaridine (24 h) shows anti-P. falciparum activity with an IC50 value of 1.53-3.94 nM[1]. |
| In Vivo | Pyronaridine (57 mg/kg, oral administration, q.d. for 30 days) reduces the parasitic burden in the Echinococcus granulosus-infected mice[2]. Pyronaridine (57 mg/kg, intraperitoneal injection, q.d. for 3 days) reduces the parasitic burden in secondarily infected (cysts) mice[2]. Pyronaridine (57 mg/kg, intraperitoneal injection, for a single dose) exhibits a higher exposure in the liver than in the plasma in male ICR mice[2]. Animal Model: Echinococcus granulosus-infected mice model[2] Dosage: 57 mg/kg Administration: Oral administration, q.d. for 30 days Result: Reduced 42.4% of parasite wet weight and killed 90.7% of secondary infection (cysts) of E. granulosus ss. |
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 621.3±55.0 °C at 760 mmHg |
| Molecular Formula | C29H32ClN5O2 |
| Molecular Weight | 518.050 |
| Flash Point | 329.6±31.5 °C |
| Exact Mass | 517.224426 |
| PSA | 76.72000 |
| LogP | 4.80 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.720 |
| Storage condition | -20℃ |