441765-97-5

441765-97-5 structure

Name: Talaglumetad hydrochloride
Chemical Name: (1S,2S,5R,6S)-2-[[(2S)-2-aminopropanoyl]amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic acid,hydrochloride
CAS Number: 441765-97-5
Molecular Formula: C₁₁H₁₇ClN₂O₅
Molecular Weight: 292.71600
Catalog: Signaling Pathways GPCR/G Protein mGluR
Create Date: 2016-11-30 12:05:07
Modify Date: 2024-01-10 17:22:22
Talaglumetad hydrochloride is a prodrug of thetype II metabotropic glutamate receptor (mGluR2/3) agonist Eglumegad for the treatment of anxiety.

Name	(1S,2S,5R,6S)-2-[[(2S)-2-aminopropanoyl]amino]bicyclo[3.1.0]hexane-2,6-dicarboxylic acid,hydrochloride
Synonyms	Talaglumetad hydrochloride (USAN) Talaglumetad hydrochloride Bicyclo(310)hexane-2,6-dicarboxylic acid,2-(((2S)-2-amino-1-oxopropyl)amino)-,monohydrochloride,(1S,2S,5R,6S) Talaglumetad HCl

Description	Talaglumetad hydrochloride is a prodrug of thetype II metabotropic glutamate receptor (mGluR2/3) agonist Eglumegad for the treatment of anxiety.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> mGluR Research Areas >> Neurological Disease
References	[1]. Kellner M, Muhtz C, Stark K, Yassouridis A, Arlt J, Wiedemann K. Effects of a metabotropic glutamate(2/3) receptor agonist (LY544344/LY354740) on panic anxiety induced by cholecystokinin tetrapeptide in healthy humans: preliminary results. Psychopharmacology (Berl). 2005;179(1):310-315. [2]. Varma MV, Eriksson AH, Sawada G, Pak YA, Perkins EJ, Zimmerman CL. Transepithelial transport of the group II metabotropic glutamate 2/3 receptor agonist (1S,2S,5R,6S)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylate (LY354740) and its prodrug (1S,2S,5R,6S)-2-[(2'S)-(2'-amino)propionyl]aminobicyclo[3.1.0]hexane-2,6-dicarboxylate (LY544344). Drug Metab Dispos. 2009;37(1):211-220. [3]. Rorick-Kehn LM, Perkins EJ, Knitowski KM, et al. Improved bioavailability of the mGlu2/3 receptor agonist LY354740 using a prodrug strategy: in vivo pharmacology of LY544344. J Pharmacol Exp Ther. 2006;316(2):905-913.