84687-47-8

84687-47-8 structure

Name: Acetytastragaloside
Chemical Name: acetylastragaloside I
CAS Number: 84687-47-8
Molecular Formula: C₄₇H₇₄O₁₇
Molecular Weight: 911.080
Catalog: Research Areas Infection
Create Date: 2018-04-04 08:00:00
Modify Date: 2024-01-07 23:32:25
Acetylastragaloside I is a glycoside that can be isolated from the roots of Astragalus baibutensis. Acetylastragaloside I is the first cycloartane-type triterpene with remarkable trypanocidal activity with IC50 values of 9.5 and 5.0 μg/mL for T. brucei rhodesiense and T. cruzi, respectively. Acetylastragaloside I can be used for the research of trypanosome infection[1].

Name	acetylastragaloside I
Synonyms	β-D-Glucopyranoside, (3β,6α,9β,16β,20R,24S)-20,24-epoxy-16,25-dihydroxy-3-[(2,3,4-tri-O-acetyl-β-D-xylopyranosyl)oxy]-9,19-cyclolanostan-6-yl Acetytastragaloside (3β,6α,9β,16β,20R,24S)-16,25-Dihydroxy-3-[(2,3,4-tri-O-acetyl-β-D-xylopyranosyl)oxy]-20,24-epoxy-9,19-cyclolanostan-6-yl β-D-glucopyranoside

Description	Acetylastragaloside I is a glycoside that can be isolated from the roots of Astragalus baibutensis. Acetylastragaloside I is the first cycloartane-type triterpene with remarkable trypanocidal activity with IC50 values of 9.5 and 5.0 μg/mL for T. brucei rhodesiense and T. cruzi, respectively. Acetylastragaloside I can be used for the research of trypanosome infection[1].
Related Catalog	Research Areas >> Infection
Target	IC50: 9.5 μg/mL (T. brucei rhodesiense), 5.0 μg/mL (T. cruzi), ＞30 μg/mL (L. donovani), ＞20 μg/mL (P. falciparum), 24.2 μg/mL (L6 cells)[1]
In Vitro	Acetylastragaloside I (0.123-90 μg/mL; 72-96 h) shows in vitro antiprotozoal activity to T. brucei rhodesiense, T. cruzi, L. donovani and P. falciparum with IC50 values of 9.5, 5.0, ＞30 and ＞20 μg/mL, respectively[1]. Acetylastragaloside I (0.123-90 μg/mL; 72 h) exhibits cytotoxicity effects to rat skeletal myoblasts (L6) cells[1]. Cell Cytotoxicity Assay[1] Cell Line: Rat skeletal myoblasts (L6) cell line Concentration: 0.123-90 μg/mL Incubation Time: 72 hours Result: Showed cytotoxicity to L6 cells with an IC50 value of 24.2 μg/mL.

Precursor 0
DownStream 2
84605-18-5 83207-58-3