Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: (SAR9,MET(O2)11)-SUBSTANCE P
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
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Zhejiang Hangyu API Co., Ltd
China
Product Name: Sar9,Met(O2)11]-Substance P
Price: $Inquiry/1kg
Purity: 99.0%
Stocking Period: 1 Day
Contact: Vinnie

110880-55-2

110880-55-2 structure

110880-55-2 structure

Name: [Sar9,Met(O2)11]-Substance P TFA
Chemical Name: [Sar9, Met(O2)11]-Substance P
CAS Number: 110880-55-2
Molecular Formula: C₆₄H₁₀₀N₁₈O₁₅S
Molecular Weight: 1393.655
Catalog: Biochemical Amino acids and their derivatives Leucine derivative
Create Date: 2018-10-23 20:11:01
Modify Date: 2024-01-02 12:59:43
[Sar9,Met(O2)11]-Substance P is a tachykinin NK1 receptor selective agonist.

Name	[Sar9, Met(O2)11]-Substance P
Synonyms	L-Leucinamide, N-(diaminomethylene)-L-ornithyl-L-prolyl-L-lysyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-phenylalanyl-L-phenylalanyl-N-methylglycyl-N-[(1S)-1-(aminocarbonyl)-3-(methylsulfonyl)propyl]- [Sar9,Met(O2)11]-Substance P N-(Diaminomethylene)-L-ornithyl-L-prolyl-L-lysyl-L-prolyl-L-glutaminyl-L-glutaminyl-L-phenylalanyl-L-phenylalanyl-N-methylglycyl-N-[(2S)-1-amino-4-(methylsulfonyl)-1-oxo-2-butanyl]-L-leucinamide MFCD00076787

Description	[Sar9,Met(O2)11]-Substance P is a tachykinin NK1 receptor selective agonist.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Neurokinin Receptor Signaling Pathways >> Neuronal Signaling >> Neurokinin Receptor Peptides Research Areas >> Neurological Disease
Target	NK1 receptor[1]
In Vitro	[Sar9,Met(O2)11]-Substance P and septide (10-100 pmol per rat, i.c.v.) are equipotent in increasing mean arterial blood pressure (MAP) and heart rate (HR), yet they have dissimilar time-course. Both agonists increase dose-dependently face washing and sniffing while [Sar9,Met(O2)11]-Substance P is the sole to produce grooming[1].
Kinase Assay	Rats initially receive an i.c.v. injection of artificial cerebrospinal fluid (aCSF; 1 μl) followed 60 min later by a single dose of either [Sar9,Met(O2)11]-Substance P (10 pmol (n=9), 25 pmol (n=9), 65 pmol (n=8) or 100 pmol (n=8)) or septide (10 pmol (n=12), 25 pmol (n=9), 65 pmol (n=6) or 100 pmol (n=6)) to construct a complete dose-response curve. Each rat is selected randomly and injected with only one of the two agonists for the remainder of the protocol. Increasing doses of [Sar9,Met(O2)11]-Substance P or septide are given at 24 h intervals on day 1 (10 pmol), day 2 (25 pmol), day 3 (65 pmol) and day 4 (100 pmol). Control rats (n=18) receive only the vehicle (aCSF) each day of experiment. Peptides are administered in a volume of 1 μL of vehicle followed by 5 μL flush volume of aCSF which corresponds to the void volume of the catheter. Each dose is calculated per rat in 1 μL solution[1].
References	[1]. Cellier E, et al. Characterization of central and peripheral effects of septide with the use of five tachykinin NK1 receptor antagonists in the rat. Br J Pharmacol. 1999 Jun;127(3):717-28.

Density	1.4±0.1 g/cm3
Molecular Formula	C₆₄H₁₀₀N₁₈O₁₅S
Molecular Weight	1393.655
Exact Mass	1392.733643
PSA	550.36000
LogP	-1.99
Index of Refraction	1.657
Storage condition	−20°C

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