123690-79-9

123690-79-9 structure

Name: CGP 35348
Chemical Name: 3-aminopropyl(diethoxymethyl)phosphinic acid
CAS Number: 123690-79-9
Molecular Formula: C₈H₂₀NO₄P
Molecular Weight: 225.22
Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
Create Date: 2018-11-25 12:17:06
Modify Date: 2024-01-08 09:40:12
CGP 35348 is a selective, brain penetrant, centrally active GABAB receptor antagonist with an EC50 of 34 μM. CGP 35348 shows affinity for the GABAB receptor only[1]. CGP 35348 has a potential to improve neuromuscular coordination and spatial learning in albino mouse following neonatal brain damage[2].

Name	3-aminopropyl(diethoxymethyl)phosphinic acid
Synonyms	Acridine Orange hydrochloride Tocris-1245 C8H20NO4P (3-Aminopropyl)(diethoxymethyl)phosphinic acid hydrate MFCD00882736

Description	CGP 35348 is a selective, brain penetrant, centrally active GABAB receptor antagonist with an EC50 of 34 μM. CGP 35348 shows affinity for the GABAB receptor only[1]. CGP 35348 has a potential to improve neuromuscular coordination and spatial learning in albino mouse following neonatal brain damage[2].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> GABA Receptor Research Areas >> Neurological Disease Signaling Pathways >> Neuronal Signaling >> GABA Receptor
In Vivo	CGP 35348 enhances non-REM sleep and rapid eye movement (REM) sleep and reduces strongly spike-wave discharges. Both behavioural and electroencephalogram (EEG) parameters contributed to the establishment of a hypnotic effect. The highest dose of CGP 35348 was not effective in promoting REM sleep. The REM-sleep-enhancing effects might have theoretical and clinical relevance. Animal Model: Eight male Wistar rats[3] Dosage: 100, 300, and 900 mg/kg Administration: Intraperitoneally given Result: Produced an increase in the duration of REM sleep compared to the saline-injected control group at 100 and 300 mg/kg.
References	[1]. H R Olpe,et al. CGP 35348: a centrally active blocker of GABAB receptors. CGP 35348: a centrally active blocker of GABAB receptors [2]. Q Gillani, et al. CGP 35348, GABA B receptor antagonist, has a potential to improve neuromuscular coordination and spatial learning in albino mouse following neonatal brain damage. Biomed Res Int. 2014;2014:295215. [3]. A Puigcerver, et al. Effects of the GABAB antagonist CGP 35348 on sleep-wake states, behaviour, and spike-wave discharges in old rats. Brain Res Bull. 1996;40(3):157-62.

Density	1.131g/cm3
Boiling Point	400.5ºC at 760mmHg
Molecular Formula	C₈H₂₀NO₄P
Molecular Weight	225.22
Flash Point	196ºC
Exact Mass	225.11300
PSA	91.59000
LogP	1.66250
Vapour Pressure	1.55E-07mmHg at 25°C
Index of Refraction	1.459
Storage condition	20°C

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